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Transient Directing Group-Assisted C-H Bond Functionalization of Aliphatic Amines: Strategies for Efficiency and Site-Selectivity

Title
Transient Directing Group-Assisted C-H Bond Functionalization of Aliphatic Amines: Strategies for Efficiency and Site-Selectivity
Authors
Ha, HyeonbinLee, JooyeonPark, Myung HwanJung, ByunghyuckKim, Min
DGIST Authors
Jung, Byunghyuck
Issue Date
2020-06
Citation
Bulletin of the Korean Chemical Society, 41(6), 582-587
Type
Article
Article Type
Article
Author Keywords
Transient directing groupTraceless directing groupTemporary directing groupC-H activationC-H functionalization
Keywords
ARYLATIONGAMMA-C(SP(3))-HPD/NORBORNENEACTIVATION
ISSN
1229-5949
Abstract
The synthesis of amine skeletons and catalytic bond formation in aliphatic amines are important synthetic methodologies. Although various metal-catalyzed organic transformations have been successfully used to functionalize and construct amine molecules, there are still many hurdles toward practical application. Moreover, site-selectivity is generally achieved using a traditional directing group (DG) strategy, which requires at least two additional steps for the installation and removal of the DGs. Recently, a transient directing group (TDG) strategy, also known as traceless DG and temporary DG, has been widely studied for a range of selective transition metal-catalyzed C─H bond functionalization. In this account, we have focused on the recent developments of the TDG strategy toward the site-selective C─H bond functionalization of aliphatic amines. The design of the TDGs used for the target reaction and their critical roles in the reaction mechanism will be covered along with their selectivity and synthetic utility. © 2020 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/12066
DOI
10.1002/bkcs.12044
Publisher
Wiley Blackwell
Related Researcher
  • Author Jung, Byunghyuck Asymmetric Organic Synthesis and Drug Synthesis Laboratory
  • Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
Files:
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Collection:
Department of Emerging Materials ScienceAsymmetric Organic Synthesis and Drug Synthesis Laboratory1. Journal Articles


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