Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gentles, Andrew J. | ko |
dc.contributor.author | Hui, Angela Bik-Yu | ko |
dc.contributor.author | Feng, Weiguo | ko |
dc.contributor.author | Azizi, Armon | ko |
dc.contributor.author | Nair, Ramesh, V | ko |
dc.contributor.author | Bouchard, Gina | ko |
dc.contributor.author | Knowles, David A. | ko |
dc.contributor.author | Yu, Alice | ko |
dc.contributor.author | Jeong, Youngtae | ko |
dc.contributor.author | Bejnood, Alborz | ko |
dc.contributor.author | Forgo, Erna | ko |
dc.contributor.author | Varma, Sushama | ko |
dc.contributor.author | Xu, Yue | ko |
dc.contributor.author | Kuong, Amanda | ko |
dc.contributor.author | Nair, Viswam S. | ko |
dc.contributor.author | West, Rob | ko |
dc.contributor.author | van de Rijn, Matt | ko |
dc.contributor.author | Hoang, Chuong D. | ko |
dc.contributor.author | Diehn, Maximilian | ko |
dc.contributor.author | Plevritis, Sylvia K. | ko |
dc.date.accessioned | 2020-07-13T09:04:59Z | - |
dc.date.available | 2020-07-13T09:04:59Z | - |
dc.date.created | 2020-05-29 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Genome Biology, v.21, no.1, pp.107 | - |
dc.identifier.issn | 1474-760X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12072 | - |
dc.description.abstract | Background: Tumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single stromal cell type, often along a single pathway. Result: To develop a deeper understanding of the interactions between cells within human lung tumors, we perform RNA-seq profiling of flow-sorted malignant cells, endothelial cells, immune cells, fibroblasts, and bulk cells from freshly resected human primary non-small-cell lung tumors. We map the cell-specific differential expression of prognostically associated secreted factors and cell surface genes, and computationally reconstruct cross-talk between these cell types to generate a novel resource called the Lung Tumor Microenvironment Interactome (LTMI). Using this resource, we identify and validate a prognostically unfavorable influence of Gremlin-1 production by fibroblasts on proliferation of malignant lung adenocarcinoma cells. We also find a prognostically favorable association between infiltration of mast cells and less aggressive tumor cell behavior. Conclusion: These results illustrate the utility of the LTMI as a resource for generating hypotheses concerning tumor-microenvironment interactions that may have prognostic and therapeutic relevance. © 2020 The Author(s). | - |
dc.language | English | - |
dc.publisher | BioMed Central Ltd. | - |
dc.title | A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13059-020-02019-x | - |
dc.identifier.wosid | 000533279400001 | - |
dc.identifier.scopusid | 2-s2.0-85084389269 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Gentles, Andrew J. | - |
dc.contributor.nonIdAuthor | Hui, Angela Bik-Yu | - |
dc.contributor.nonIdAuthor | Feng, Weiguo | - |
dc.contributor.nonIdAuthor | Azizi, Armon | - |
dc.contributor.nonIdAuthor | Nair, Ramesh, V | - |
dc.contributor.nonIdAuthor | Bouchard, Gina | - |
dc.contributor.nonIdAuthor | Knowles, David A. | - |
dc.contributor.nonIdAuthor | Yu, Alice | - |
dc.contributor.nonIdAuthor | Bejnood, Alborz | - |
dc.contributor.nonIdAuthor | Forgo, Erna | - |
dc.contributor.nonIdAuthor | Varma, Sushama | - |
dc.contributor.nonIdAuthor | Xu, Yue | - |
dc.contributor.nonIdAuthor | Kuong, Amanda | - |
dc.contributor.nonIdAuthor | Nair, Viswam S. | - |
dc.contributor.nonIdAuthor | West, Rob | - |
dc.contributor.nonIdAuthor | van de Rijn, Matt | - |
dc.contributor.nonIdAuthor | Hoang, Chuong D. | - |
dc.contributor.nonIdAuthor | Diehn, Maximilian | - |
dc.contributor.nonIdAuthor | Plevritis, Sylvia K. | - |
dc.identifier.citationVolume | 21 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationStartPage | 107 | - |
dc.identifier.citationTitle | Genome Biology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL NETWORK | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | MODULATORS | - |
dc.contributor.affiliatedAuthor | Jeong, Youngtae | - |