Characterization of a novel regulatory mechanism for FMRP through an Ataxin-2-PABP complex

Abstract

Ataxin-2 and FMRP have been known the most important factor in neurodegenerative, neurodevelopmental disease. However, it is very difficult to specify the function of Ataxin-2 and FMRP because of the various disease types. Although recent study reported that a direct interaction between Ataxin-2 and FMRP, the specific function and regulatory pathway are elusive. Interestingly, we found the increased amount of Ataxin-2 causes dysregulation of FMRP and defects of dendrite morphology in highly complicated neuron. Furthermore, we observed these phenomena can be occurred depending on PABP or motor protein, which is most popular binding partner of Ataxin-2 and FMRP. These results suggest that a specific regulatory mechanism of FMRP with Ataxin-2-PABP complex, and we expected that it contributes to reveal the detailed interaction of Ataxin-2, PABP, and FMRP.