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Characterization of a novel regulatory mechanism for FMRP through an Ataxin-2-PABP complex

Title
Characterization of a novel regulatory mechanism for FMRP through an Ataxin-2-PABP complex
Translated Title
Ataxin-2-PABP 구조의 FMRP 조절 기작에 관한 연구
Authors
Seung Yeol, Kim
DGIST Authors
Kim, Seung Yeol; Kim, Ho Min; Lee, Sung Bae
Advisor(s)
이성배
Co-Advisor(s)
Ho Min Kim
Issue Date
2020
Available Date
2020-08-06
Degree Date
2020-02
Type
Thesis
Description
Ataxin-2, PABP, FMRP, Motor protein
Abstract
Ataxin-2 and FMRP have been known the most important factor in neurodegenerative, neurodevelopmental disease. However, it is very difficult to specify the function of Ataxin-2 and FMRP because of the various disease types. Although recent study reported that a direct interaction between Ataxin-2 and FMRP, the specific function and regulatory pathway are elusive. Interestingly, we found the increased amount of Ataxin-2 causes dysregulation of FMRP and defects of dendrite morphology in highly complicated neuron. Furthermore, we observed these phenomena can be occurred depending on PABP or motor protein, which is most popular binding partner of Ataxin-2 and FMRP. These results suggest that a specific regulatory mechanism of FMRP with Ataxin-2-PABP complex, and we expected that it contributes to reveal the detailed interaction of Ataxin-2, PABP, and FMRP.
Table Of Contents
Abstract i List of Contents ii List of Figures iii List of Tables iv I. INTRODUCTION 1 1.1 Representative function of Ataxin-2 and its relationship with neurodegenerative diseases 1 1.2 Representative function of FMRP and Fragile X associated disorder and diseases 2 1.3 Interaction of Ataxin-2 and FMRP 2 II. MATERIALS AND METHODS 5 III. RESULTS 8 3.1 Reducing tendency of endogenous or exogenous expressed dFMR1 is observed in dATX2 overexpression flies 8 3.2 Overexpression of dATX2 induces dysregulation of dFMR1 and severe defects of dendrite morphology in Drosophila class IV da neuron 15 3.3 Dysregulation of dFMR1 and dendrite defects can be associated with PABP and motor proteins 18 IV. DISCUSSION 25 V. REFERENCES 27 VI. SUMMARY (국문요약) 29
URI
http://dgist.dcollection.net/common/orgView/200000281564
http://hdl.handle.net/20.500.11750/12168
DOI
10.22677/Theses.200000281564
Degree
Master
Department
Brain and Cognitive Sciences
University
DGIST
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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Collection:
Department of Brain and Cognitive SciencesThesesMaster


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