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dc.contributor.author Yoo, Seung Jun -
dc.contributor.author Son, Gowoon -
dc.contributor.author Bae, Jisub -
dc.contributor.author Kim, So Yeun -
dc.contributor.author Yoo, Yong Kyoung -
dc.contributor.author Park, Dongsung -
dc.contributor.author Baek, Seung Yeop -
dc.contributor.author Chang, Keun-A -
dc.contributor.author Suh, Yoo-Hun -
dc.contributor.author Lee, Yeong-Bae -
dc.contributor.author Hwang, Kyo Seon -
dc.contributor.author Kim, YoungSoo -
dc.contributor.author Moon, Cheil -
dc.date.accessioned 2020-09-02T07:44:38Z -
dc.date.available 2020-09-02T07:44:38Z -
dc.date.created 2020-07-30 -
dc.date.issued 2020-07 -
dc.identifier.citation Scientific Reports, v.10, no.1, pp.11234 -
dc.identifier.issn 2045-2322 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12353 -
dc.description.abstract Despite clinical evidence indicating a close relationship between olfactory dysfunction and Alzheimer’s disease (AD), further investigations are warranted to determine the diagnostic potential of nasal surrogate biomarkers for AD. In this study, we first identified soluble amyloid-β (Aβ), the key biomarker of AD, in patient nasal discharge using proteomic analysis. Then, we profiled the significant differences in Aβ oligomers level between patient groups with mild or moderate cognitive decline (n = 39) and an age-matched normal control group (n = 21) by immunoblot analysis and comparing the levels of Aβ by a self-standard method with interdigitated microelectrode sensor systems. All subjects received the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and the Global Deterioration Scale (GDS) for grouping. We observed higher levels of Aβ oligomers in probable AD subjects with lower MMSE, higher CDR, and higher GDS compared to the normal control group. Moreover, mild and moderate subject groups could be distinguished based on the increased composition of two oligomers, 12-mer Aβ*56 and 15-mer AβO, respectively. The longitudinal cohort study confirmed that the cognitive decline of mild AD patients with high nasal discharge Aβ*56 levels advanced to the moderate stage within three years. Our clinical evidence strongly supports the view that the presence of oligomeric Aβ proteins in nasal discharge is a potential surrogate biomarker of AD and an indicator of cognitive decline progression. © 2020, The Author(s). -
dc.language English -
dc.publisher Nature Publishing Group -
dc.title Longitudinal profiling of oligomeric A beta in human nasal discharge reflecting cognitive decline in probable Alzheimer's disease -
dc.type Article -
dc.identifier.doi 10.1038/s41598-020-68148-2 -
dc.identifier.wosid 000548301200016 -
dc.identifier.scopusid 2-s2.0-85087717392 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Scientific Reports -
dc.contributor.nonIdAuthor Yoo, Seung Jun -
dc.contributor.nonIdAuthor Son, Gowoon -
dc.contributor.nonIdAuthor Bae, Jisub -
dc.contributor.nonIdAuthor Kim, So Yeun -
dc.contributor.nonIdAuthor Yoo, Yong Kyoung -
dc.contributor.nonIdAuthor Park, Dongsung -
dc.contributor.nonIdAuthor Baek, Seung Yeop -
dc.contributor.nonIdAuthor Chang, Keun-A -
dc.contributor.nonIdAuthor Suh, Yoo-Hun -
dc.contributor.nonIdAuthor Lee, Yeong-Bae -
dc.contributor.nonIdAuthor Hwang, Kyo Seon -
dc.contributor.nonIdAuthor Kim, YoungSoo -
dc.identifier.citationVolume 10 -
dc.identifier.citationNumber 1 -
dc.identifier.citationStartPage 11234 -
dc.identifier.citationTitle Scientific Reports -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordPlus AMYLOID-BETA -
dc.subject.keywordPlus OLFACTORY DYSFUNCTION -
dc.subject.keywordPlus NATIONAL INSTITUTE -
dc.subject.keywordPlus ASSOCIATION WORKGROUPS -
dc.subject.keywordPlus DIAGNOSTIC GUIDELINES -
dc.subject.keywordPlus CLINICAL-TRIALS -
dc.subject.keywordPlus DEMENTIA -
dc.subject.keywordPlus PROTEIN -
dc.subject.keywordPlus IMPAIRMENT -
dc.subject.keywordPlus BIOMARKERS -
dc.contributor.affiliatedAuthor Yoo, Seung Jun -
dc.contributor.affiliatedAuthor Son, Gowoon -
dc.contributor.affiliatedAuthor Bae, Jisub -
dc.contributor.affiliatedAuthor Kim, So Yeun -
dc.contributor.affiliatedAuthor Yoo, Yong Kyoung -
dc.contributor.affiliatedAuthor Park, Dongsung -
dc.contributor.affiliatedAuthor Baek, Seung Yeop -
dc.contributor.affiliatedAuthor Chang, Keun-A -
dc.contributor.affiliatedAuthor Suh, Yoo-Hun -
dc.contributor.affiliatedAuthor Lee, Yeong-Bae -
dc.contributor.affiliatedAuthor Hwang, Kyo Seon -
dc.contributor.affiliatedAuthor Kim, YoungSoo -
dc.contributor.affiliatedAuthor Moon, Cheil -
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Appears in Collections:
Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles

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