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Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease

Title
Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease
Authors
Seo, JincheolWon, JinyoungKim, KeonwooPark, JunghyungYeo, Hyeon-GuKim, Yu GyeongBaek, Seung HoLee, HoonwonJeon, Chang-YeopChoi, Won SeokLee, SangilKim, Ki JinPark, Sung-HyunSon, YeonghoonJeong, Kang JinLim, Kyung SeobKang, PhilyongLee, Hwal-YongSon, Hee-ChangHuh, Jae-WonKim, Young-HyunLee, Dong-SeokLee, Sang-RaeChoi, Ji-WoongLee, Youngjeon
DGIST Authors
Seo, Jincheol; Won, Jinyoung; Kim, Keonwoo; Park, Junghyung; Yeo, Hyeon-Gu; Kim, Yu Gyeong; Baek, Seung Ho; Lee, Hoonwon; Jeon, Chang-Yeop; Choi, Won Seok; Lee, Sangil; Kim, Ki Jin; Park, Sung-Hyun; Son, Yeonghoon; Jeong, Kang Jin; Lim, Kyung Seob; Kang, Philyong; Lee, Hwal-Yong; Son, Hee-Chang; Huh, Jae-Won; Kim, Young-Hyun; Lee, Dong-Seok; Lee, Sang-Rae; Choi, Ji-Woong; Lee, Youngjeon
Issue Date
2020-10
Citation
Experimental Neurobiology, 29(5), 376-388
Type
Article
Article Type
Article
Author Keywords
Parkinson&aposs diseaseNon-human primateHand dexterity functionHand dexterity taskTremor
Keywords
ANIMAL-MODELSMONKEY MODELMPTPMOVEMENTDIAGNOSISRECOVERYMOTOR FUNCTIONINTRACEREBROVENTRICULAR INJECTIONFINGER DEXTERITYPOSTURAL TREMOR
ISSN
1226-2560
Abstract
Symptoms of Parkinson's disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors. Copyright © Experimental Neurobiology 2020.
URI
http://hdl.handle.net/20.500.11750/12574
DOI
10.5607/en20040
Publisher
Korean Society for Neurodegenerative Disease
Related Researcher
  • Author Choi, Ji-Woong CSP(Communication and Signal Processing) Lab
  • Research Interests Communication System; Signal Processing; Communication Circuit Design; 생체 신호 통신 및 신호 처리; 뇌-기계 인터페이스(BMI); 차세대 교차계층 통신 및 신호 처리; 5G 모바일 통신
Files:
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Collection:
Department of Information and Communication EngineeringCSP(Communication and Signal Processing) Lab1. Journal Articles


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