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Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment

Title
Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment
Authors
Lee, DavinJo, Min GuKim, Seung YeonChung, Chang GeonLee, Sung Bae
DGIST Authors
Lee, Davin; Jo, Min Gu; Kim, Seung Yeon; Chung, Chang Geon; Lee, Sung Bae
Issue Date
2020-11
Citation
Antioxidants, 9(11), 1056
Type
Article
Article Type
Review
Author Keywords
dietary antioxidantsmitochondriareactive oxygen speciesneurodegenerative diseaseParkinson&#8217s diseasemitochondrial quality control
Keywords
AGING-RELATED CHANGESOXIDATIVE STRESSMOLECULAR-MECHANISMSVITAMIN-EDOPAMINERGIC-NEURONSTEA POLYPHENOLRAT MODELIN-VITRODYSFUNCTIONCELL
ISSN
2076-3921
Abstract
Advances in medicine and dietary standards over recent decades have remarkably increased human life expectancy. Unfortunately, the chance of developing age‐related diseases, including neurodegenerative diseases (NDDs), increases with increased life expectancy. High metabolic demands of neurons are met by mitochondria, damage of which is thought to contribute to the development of many NDDs including Parkinson’s disease (PD). Mitochondrial damage is closely associated with the abnormal production of reactive oxygen species (ROS), which are widely known to be toxic in various cellular environments, including NDD contexts. Thus, ways to prevent or slow mitochondrial dysfunction are needed for the treatment of these NDDs. In this review, we first detail how ROS are associated with mitochondrial dysfunction and review the cellular mechanisms, such as the mitochondrial quality control (MQC) system, by which neurons defend against both abnormal production of ROS and the subsequent accumulation of damaged mitochondria. We next highlight previous studies that link mitochondrial dysfunction with PD and how dietary antioxidants might provide reinforcement of the MQC system. Finally, we discuss how aging plays a role in mitochondrial dysfunction and PD before considering how healthy aging through proper diet and exercise may be salutary. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/12685
DOI
10.3390/antiox9111056
Publisher
MDPI AG
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles


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