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Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF-16/FOXO

Title
Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF-16/FOXO
Authors
Park, SangsoonArtan, MuratJeong, Dae‐EunPark, Hae‐Eun H.Son, Heehwa G.Kim, Sieun S.Jung, YoonjiChoi, YunjiLee, Jin I.Kim, KyuhyungLee, Seung‐Jae V.
DGIST Authors
Park, Sangsoon; Artan, Murat; Jeong, Dae‐Eun; Park, Hae‐Eun H.; Son, Heehwa G.; Kim, Sieun S.; Jung, Yoonji; Choi, Yunji; Lee, Jin I.; Kim, Kyuhyung; Lee, Seung‐Jae V.
Issue Date
2021-01
Citation
Aging Cell, 20(1), e13300
Type
Article
Article Type
Article
Author Keywords
agingC. elegansdiacetyldietary restrictionlongevity
Keywords
LIFE-SPANCAENORHABDITIS-ELEGANSDIETARY RESTRICTIONOLFACTIONRESPONSES
ISSN
1474-9718
Abstract
Dietary restriction extends lifespan in various organisms by reducing the levels of both nutrients and non-nutritional food-derived cues. However, the identity of specific food-derived chemical cues that alter lifespan remains unclear. Here, we identified several volatile attractants that decreased the longevity on food deprivation, a dietary restriction regimen in Caenorhabditis elegans. In particular, we found that the odor of diacetyl decreased the activity of DAF-16/FOXO, a life-extending transcription factor acting downstream of insulin/IGF-1 signaling. We then demonstrated that the odor of lactic acid bacteria, which produce diacetyl, reduced the nuclear accumulation of DAF-16/FOXO. Unexpectedly, we showed that the odor of diacetyl decreased longevity independently of two established diacetyl receptors, ODR-10 and SRI-14, in sensory neurons. Thus, diacetyl, a food-derived odorant, may shorten food deprivation-induced longevity via decreasing the activity of DAF-16/FOXO through binding to unidentified receptors. © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
URI
http://hdl.handle.net/20.500.11750/12700
DOI
10.1111/acel.13300
Publisher
Blackwell Publishing Ltd
Related Researcher
  • Author Kim, Kyuhyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
Files:
Collection:
Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


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