Cited 2 time in webofscience Cited 2 time in scopus

Nogo-A regulates myogenesis via interacting with Filamin-C

Title
Nogo-A regulates myogenesis via interacting with Filamin-C
Authors
Park, SunYoungPark, Ji HwanKang, Un-BeomChoi, Seong-KyoonElfadi, AhmedUllah, H M ArifChung, Myung-JinSon, Ji-YoonYun, Hyun HoPark, Jae-MinYim, Jae-HyukJung, Seung-JunKim, Sang-HyupChoi, Young-ChulKim, Dae-SeongShin, Jin-HongPark, Jin-SungHur, KeunLee, Sang-HanLee, Eun-JooHwang, DaeheeJeong, Kyu-Shik
DGIST Authors
Choi, Seong-Kyoon
Issue Date
2021-01
Citation
Cell Death Discovery, 7(1), 1
Type
Article
Article Type
Article
Keywords
NEURITE OUTGROWTHCIRCADIAN-RHYTHMSRECEPTORINHIBITORCELLSDIFFERENTIATIONGLYCOPROTEINLIGANDCLOCKMYOD
ISSN
2058-7716
Abstract
Among the three isoforms encoded by Rtn4, Nogo-A has been intensely investigated as a central nervous system inhibitor. Although Nogo-A expression is increased in muscles of patients with amyotrophic lateral sclerosis, its role in muscle homeostasis and regeneration is not well elucidated. In this study, we discovered a significant increase in Nogo-A expression in various muscle-related pathological conditions. Nogo−/− mice displayed dystrophic muscle structure, dysregulated muscle regeneration following injury, and altered gene expression involving lipid storage and muscle cell differentiation. We hypothesized that increased Nogo-A levels might regulate muscle regeneration. Differentiating myoblasts exhibited Nogo-A upregulation and silencing Nogo-A abrogated myoblast differentiation. Nogo-A interacted with filamin-C, suggesting a role for Nogo-A in cytoskeletal arrangement during myogenesis. In conclusion, Nogo-A maintains muscle homeostasis and integrity, and pathologically altered Nogo-A expression mediates muscle regeneration, suggesting Nogo-A as a novel target for the treatment of myopathies in clinical settings. © 2021, The Author(s).
URI
http://hdl.handle.net/20.500.11750/12747
DOI
10.1038/s41420-020-00384-x
Publisher
Nature Publishing Group
Related Researcher
Files:
There are no files associated with this item.
Collection:
Division of Biotechnology1. Journal Articles


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