Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jang, Hye-Mi | - |
dc.contributor.author | Park, Ji-Yeon | - |
dc.contributor.author | Lee, Yeon-Ji | - |
dc.contributor.author | Kang, Min-Jung | - |
dc.contributor.author | Jo, Sung-Gang | - |
dc.contributor.author | Jeong, Yu-Jin | - |
dc.contributor.author | Cho, Nam-Pyo | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Kim, Dong-Jae | - |
dc.contributor.author | Park, Jong-Hwan | - |
dc.date.accessioned | 2021-01-22T07:23:58Z | - |
dc.date.available | 2021-01-22T07:23:58Z | - |
dc.date.created | 2021-01-07 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12748 | - |
dc.description.abstract | Prevotella nigrescens is an oral pathogen that is frequently observed in the subgingival plaque of periodontitis patients. Interleukin-1β (IL-1β) is known to be involved in the immunopathology of periodontal diseases and has been implicated in the destruction of bone. In this study, we investigated the mechanism of IL-1β production by P. nigrescens in murine bone marrow-derived dendritic cells (BMDCs). Our results showed that a host receptor, Toll-like receptor 2 (TLR2), but not TLR4 is required for pro-IL-1β induction and nucleotide-binding oligomerization domain like receptor pyrin domain containing 3 (NLRP3) priming in BMDCs in response to P. nigrescens and activation of the NLRP3 inflammasome is necessary for processing of pro-IL-1β into mature IL-1β. In addition, an inhibitor assay revealed that production of reactive oxygen species, P2X7R activity, and release of cathepsin B are involved in IL-1β production in BMDCs in response to P. nigrescens. © The author(s). | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.title | Tlr2 and the nlrp3 inflammasome mediate il-1β production in prevotella nigrescens-infected dendritic cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.7150/ijms.47197 | - |
dc.identifier.scopusid | 2-s2.0-85097674710 | - |
dc.identifier.bibliographicCitation | International Journal of Medical Sciences, v.18, no.2, pp.432 - 440 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Prevotella nigrescens | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordAuthor | TLR2 | - |
dc.subject.keywordAuthor | NLRP3 inflammasome | - |
dc.subject.keywordAuthor | BMDCs | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | AGGREGATIBACTER-ACTINOMYCETEMCOMITANS | - |
dc.subject.keywordPlus | FUSOBACTERIUM-NUCLEATUM | - |
dc.subject.keywordPlus | P2X7 RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | CASPASE-1 | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | FLAGELLIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.citation.endPage | 440 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 432 | - |
dc.citation.title | International Journal of Medical Sciences | - |
dc.citation.volume | 18 | - |