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Biophysical underpinnings regarding the formation and the regulation of biomolecular condensates
- Title
- Biophysical underpinnings regarding the formation and the regulation of biomolecular condensates
- Authors
- Kim, Jinkwang; Gwak, Eunha; Lee, Jong-Chan
- DGIST Authors
- Kim, Jinkwang; Gwak, Eunha; Lee, Jong-Chan
- Issue Date
- 2021-03
- Citation
- Journal of the Korean Physical Society, 78(5), 393-400
- Type
- Article
- Article Type
- Review
- Author Keywords
- Biomolecular condensates; Liquid-liquid phase separation
- Keywords
- INTRINSICALLY DISORDERED PROTEINS; PHASE-SEPARATION; TRANSITION; PROMOTES; SIZE; COMPLEXES; COMPONENT; NUCLEOLI; SPECKLES; DYNAMICS
- ISSN
- 0374-4884
- Abstract
- For effective of orchestration of biochemical reactions that are optimized in different physicochemical environments, cells are evolved to carry various non-membranous biomolecular condensates in addition to conventional membrane-bound organelles. Recent studies have revealed that these biomolecular condensates are made up of proteins and RNAs of a specific character and are formed via liquid–liquid phase separation. Here, we review recent theoretical attempts trying to understand the biophysical principles underlying the formation and regulation of these intriguing structures. Comprehension of the biophysical underpinnings regarding the occurrence and the behavior of biomolecular condensates will make deeper insights into their biological functions possible. © 2021, The Korean Physical Society.
- URI
- http://hdl.handle.net/20.500.11750/12983
- DOI
- 10.1007/s40042-021-00073-7
- Publisher
- 한국물리학회
- Related Researcher
-
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Lee, Jong-Chan
Single-molecule Biophysics and Advanced Bioimaging Laboratory
-
Research Interests
Liquid-liquid phase separation; Super-resolution imaging;
- Files:
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- Collection:
- Department of New BiologySingle-molecule Biophysics and Advanced Bioimaging Laboratory1. Journal Articles
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