Cited 0 time in webofscience Cited 0 time in scopus

Biophysical underpinnings regarding the formation and the regulation of biomolecular condensates

Title
Biophysical underpinnings regarding the formation and the regulation of biomolecular condensates
Authors
Kim, JinkwangGwak, EunhaLee, Jong-Chan
DGIST Authors
Kim, Jinkwang; Gwak, Eunha; Lee, Jong-Chan
Issue Date
2021-03
Citation
Journal of the Korean Physical Society, 78(5), 393-400
Type
Article
Article Type
Review
Author Keywords
Biomolecular condensatesLiquid-liquid phase separation
Keywords
INTRINSICALLY DISORDERED PROTEINSPHASE-SEPARATIONTRANSITIONPROMOTESSIZECOMPLEXESCOMPONENTNUCLEOLISPECKLESDYNAMICS
ISSN
0374-4884
Abstract
For effective of orchestration of biochemical reactions that are optimized in different physicochemical environments, cells are evolved to carry various non-membranous biomolecular condensates in addition to conventional membrane-bound organelles. Recent studies have revealed that these biomolecular condensates are made up of proteins and RNAs of a specific character and are formed via liquid–liquid phase separation. Here, we review recent theoretical attempts trying to understand the biophysical principles underlying the formation and regulation of these intriguing structures. Comprehension of the biophysical underpinnings regarding the occurrence and the behavior of biomolecular condensates will make deeper insights into their biological functions possible. © 2021, The Korean Physical Society.
URI
http://hdl.handle.net/20.500.11750/12983
DOI
10.1007/s40042-021-00073-7
Publisher
한국물리학회
Related Researcher
  • Author Lee, Jong-Chan Single-molecule Biophysics and Advanced Bioimaging Laboratory
  • Research Interests Liquid-liquid phase separation; Super-resolution imaging;
Files:
There are no files associated with this item.
Collection:
Department of New BiologySingle-molecule Biophysics and Advanced Bioimaging Laboratory1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE