Department of Brain Sciences Laboratory of Protein Biophysics 3. Patents
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열민감성이 향상된 돌연변이 UDG

Title
열민감성이 향상된 돌연변이 UDG
Alternative Title
Mutant Uracil DNA Glycosylase with increased thermal sensitivity
Author(s)
서민재 ; 남기훈 ; 이주환 ; 박성준 ; 임슬기 ; 윤정연 ; 신용걸 ; 유우경 ; 강무석 ; 김상열
Country
KO
Application Date
2019-08-06
Application No.
10-2019-0095291
Registration Date
2020-10-19
Publication No.
10-2169528
Assignee
(주)엔지노믹스(82/82),(재)대구경북과학기술원(18/18)
URI
http://hdl.handle.net/20.500.11750/13063 10-2019-0095291
Abstract
본원은 야생형대비 열민감성이 증가된 돌연변이 UDG를 개시한다. 본원에 따른 돌연변이 UDG는 높은 열민감성으로 PCR 반응의 저해 효과가 없어 PCR/qPCR PreMIX의 개발은 물론, 특히 낮은 melting 및 amplification step 이 필요한 실험에 보다 적합한 UDG 적용 PCR 진단 키트 개발을 가능하게 한다.
Related Researcher
  • 유우경 Yu, Wookyung
  • Research Interests protein biophysics; protein folding; protein dynamics and conformational change
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