Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, Jong-Chan | - |
dc.contributor.author | Jang, So-Yeong | - |
dc.contributor.author | Lee, Dongjoon | - |
dc.contributor.author | Lee, Jeongha | - |
dc.contributor.author | Kang, Uiryong | - |
dc.contributor.author | Chang, Hongjun | - |
dc.contributor.author | Kim, Haeng Jun | - |
dc.contributor.author | Han, Sun-Ho | - |
dc.contributor.author | Seo, Jinsoo | - |
dc.contributor.author | Choi, Murim | - |
dc.contributor.author | Lee, Dong Young | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Cho, Kwang-Hyun | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.date.accessioned | 2021-04-29T12:30:29Z | - |
dc.date.available | 2021-04-29T12:30:29Z | - |
dc.date.created | 2021-01-22 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/13478 | - |
dc.description.abstract | Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood–brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs. © 2021, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-020-20440-5 | - |
dc.identifier.scopusid | 2-s2.0-85099185691 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.12, no.1, pp.280 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | brain | - |
dc.subject.keywordPlus | cell component | - |
dc.subject.keywordPlus | drug development | - |
dc.subject.keywordPlus | genetic engineering | - |
dc.subject.keywordPlus | medicine | - |
dc.subject.keywordPlus | mental health | - |
dc.subject.keywordPlus | nervous system disorder | - |
dc.subject.keywordPlus | pathology | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 280 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 12 | - |