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Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy

Title
Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy
Authors
Jung, InseongJung, DokyungZha, ZhaoJeong, JongwonNoh, SoojeongShin, JiwonPark, Jun-KookKim, Kwang-SooJeong, YoungtaeHur, JinBaek, Moon-ChangDiaz-Aguilar, SophiaAguilar, EdithFriedlander, MartinBucher, FelicitasYea, Kyungmoo
DGIST Authors
Jung, Inseong; Jung, Dokyung; Zha, Zhao; Jeong, Jongwon; Noh, Soojeong; Shin, Jiwon; Park, Jun-Kook; Kim, Kwang-Soo; Jeong, Youngtae; Hur, Jin; Baek, Moon-Chang; Diaz-Aguilar, Sophia; Aguilar, Edith; Friedlander, Martin; Bucher, Felicitas; Yea, Kyungmoo
Issue Date
2021-07
Citation
Cytokine, 143, 155542
Type
Article
Author Keywords
AngiogenesisEndothelial cellsIFNGTube formationVEGFaWound healing
Keywords
OXYGEN-INDUCED RETINOPATHYCYTOKINE FUSION PROTEINSENDOTHELIAL-CELLS
ISSN
1043-4666
Abstract
Interferon-γ (IFNG) is one of the key cytokines that regulates both innate and adaptive immune responses in the body. However, the role of IFNG in the regulation of vascularization, especially in the context of Vascular endothelial growth factor A (VEGFa)-induced angiogenesis is not clarified. Here, we report that IFNG shows potent anti-angiogenic potential against VEGFa-induced angiogenesis. IFNG significantly inhibited proliferation, migration, and tube formation of Human umbilical vein endothelial cells (HUVECs) both under basal and VEGFa-treated conditions. Intriguingly, Knockdown (KD) of STAT1 abolished the inhibitory effect of IFNG on VEGFa-induced angiogenic processes in HUVECs. Furthermore, IFNG exhibited potent anti-angiogenic efficacy in the mouse model of oxygen-induced retinopathy (OIR), an in vivo model for hypoxia-induced retinal neovascularization, without induction of functional side effects. Taken together, these results show that IFNG plays a crucial role in the regulation of VEGFa-dependent angiogenesis, suggesting its potential therapeutic applicability in neovascular diseases. © 2021 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/13757
DOI
10.1016/j.cyto.2021.155542
Publisher
Academic Press
Related Researcher
  • Author Yea, Kyungmoo Protein Engineering Lab
  • Research Interests Antibody, Engineering, Phage Display, Therapeutics, Immune, Exosome, Translational, Cytokine
Files:
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Collection:
Department of New BiologyLab of Stem Cell Biology & Cancer Precision Medicine1. Journal Articles
Department of New BiologyProtein Engineering Lab1. Journal Articles


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