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Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals

Title
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals
Author(s)
Baek, Su-MinLee, Seoung-WooKim, Tae-UnChoi, Seong-KyoonYun, SunghoLee, Won-JaeHan, Se-HyeonHong, Il-HwaPark, Sang-JoonKim, Tae-HwanJeong, Kyu-ShikPark, Jin-Kyu
Issued Date
2021-03
Citation
International Journal of Molecular Sciences, v.22, no.5, pp.2340 - 18
Type
Article
Author Keywords
breast cancercatdiagnostic markerdoghumanmammary carcinomaneoplastic glandular epithelial cellSMP30
Keywords
CANINE MAMMARY-TUMORSCLINICOPATHOLOGICAL FEATURESPROGESTERONE-RECEPTORSDEFICIENCY INCREASESYOUNG-WOMENAPOPTOSISREGUCALCINSTRESSAGEROS
ISSN
1661-6596
Abstract
Senescence marker protein 30 (SMP30) is a cell survival factor playing an important role in vitamin C synthesis and antiapoptosis. Moreover, its cytoprotective role suggests a possibility to be related to cancer cell survival. Mammary carcinoma is a common cancer in both humans and animals. Because of its histopathological diversity, especially in the early stage, histopathological diagnosis may be complicated; therefore, a diagnostic marker is helpful for confirmation. The present study analyzed the expression pattern of SMP30 in mammary carcinoma in humans, dogs, and cats. Immunohistochemistry, immunofluorescence, and western blot analysis were used to investigate SMP30 expression patterns. The expression was specifically observed in neoplastic glandular epithelial cells. The expression increased with the malignancy of glandular epithelial cells with a highly proliferative status. However, SMP30 expression was low in normal mammary gland tissues or well-differentiated adenoma tissues. The patterns were consistently reproduced in canine primary mammary carcinoma cells and MCF-7 and MDA-MB-231 human carcinoma cell lines. This study provides useful information to understand SMP30 expression in various stages of mammary carcinoma and to suggest its utility as a pan-species diagnostic marker, thereby helping to establish strategies for diagnosing mammary carcinoma in several species.
URI
http://hdl.handle.net/20.500.11750/15328
DOI
10.3390/ijms22052340
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
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Appears in Collections:
Division of Biomedical Technology 1. Journal Articles

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