Cited 0 time in webofscience Cited 1 time in scopus

Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells

Title
Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
Authors
Lim, YunKim, SeolsongKim, Eun-Kyoung
DGIST Authors
Lim, Yun; Kim, Seolsong; Kim, Eun-Kyoung
Issue Date
2021-04
Citation
Molecular Brain, 14(1), 65
Type
Article
Author Keywords
PalmitateER stressAutophagyER-phagyStarvationHypothalamic cells
ISSN
1756-6606
Abstract
Palmitate is a saturated fatty acid that is well known to induce endoplasmic reticulum (ER) stress and autophagy. A high-fat diet increases the palmitate level in the hypothalamus, the main region of the brain regulating energy metabolism. Interestingly, hypothalamic palmitate level is also increased under starvation, urging the study to distinguish the effects of elevated hypothalamic palmitate level under different nutrient conditions. Herein, we show that ER-phagy (ER-targeted selective autophagy) is required for progress of ER stress and that palmitate decreases ER stress by inhibiting ER-phagy in hypothalamic cells under starvation. Palmitate inhibited starvation-induced ER-phagy by increasing the level of B-cell lymphoma 2 (Bcl-2) protein, which inhibits autophagy initiation. These findings suggest that, unlike the induction of ER stress under nutrient-rich conditions, palmitate protects hypothalamic cells from starvation-induced stress by inhibiting ER-phagy. © 2021, The Author(s).
URI
http://hdl.handle.net/20.500.11750/15396
DOI
10.1186/s13041-021-00777-8
Publisher
BioMed Central
Related Researcher
  • Author Kim, Eun-Kyoung Lab of Neuro-Metabolism & Neurometabolomic Research Center
  • Research Interests Neural functions in metabolic diseases; 뇌신경세포와 비만; 당뇨 등의 대사 질환 관련 연구
Files:
Collection:
Department of Brain SciencesLab of Neuro-Metabolism & Neurometabolomic Research Center1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE