Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Vadevoo, Sir Murugan Poongkavithai | - |
dc.contributor.author | Gunassekaran, Gowri Rangaswarmy | - |
dc.contributor.author | Lee, ChaeEun | - |
dc.contributor.author | Lee, NaHye | - |
dc.contributor.author | Lee, Jiyoun | - |
dc.contributor.author | Chae, Sehyun | - |
dc.contributor.author | Park, Jae-Yong | - |
dc.contributor.author | Koo, JaeHyung | - |
dc.contributor.author | Lee, Byungheon | - |
dc.date.accessioned | 2021-10-11T13:30:06Z | - |
dc.date.available | 2021-10-11T13:30:06Z | - |
dc.date.created | 2021-09-30 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, v.118, no.37 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15460 | - |
dc.description.abstract | Expression and function of odorant receptors (ORs), which account for more than 50% of G protein-coupled receptors, are being increasingly reported in nonolfactory sites. However, ORs that can be targeted by drugs to treat diseases remain poorly identified. Tumorderived lactate plays a crucial role in multiple signaling pathways leading to generation of tumor-associated macrophages (TAMs). In this study, we hypothesized that the macrophage OR Olfr78 functions as a lactate sensor and shapes the macrophage-tumor axis. Using Olfr78+/+ and Olfr78-/- bone marrow-derived macrophages with or without exogenous Olfr78 expression, we demonstrated that Olfr78 sensed tumor-derived lactate, whichwas themain factor in tumor-conditioned media responsible for generation of protumoral M2-TAMs. Olfr78 functioned together with Gpr132 to mediate lactate-induced generation of protumoral M2-TAMs. In addition, syngeneic Olfr78-deficient mice exhibited reduced tumor progression and metastasis together with an increased anti- versus protumoral immune cell population. We propose that the Olfr78-lactate interaction is a therapeutic target to reduce and prevent tumor progression and metastasis. © 2021 National Academy of Sciences. All rights reserved. | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.title | The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2102434118 | - |
dc.identifier.wosid | 000697000500012 | - |
dc.identifier.scopusid | 2-s2.0-85114726952 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.contributor.nonIdAuthor | Vadevoo, Sir Murugan Poongkavithai | - |
dc.contributor.nonIdAuthor | Gunassekaran, Gowri Rangaswarmy | - |
dc.contributor.nonIdAuthor | Lee, ChaeEun | - |
dc.contributor.nonIdAuthor | Lee, NaHye | - |
dc.contributor.nonIdAuthor | Lee, Jiyoun | - |
dc.contributor.nonIdAuthor | Chae, Sehyun | - |
dc.contributor.nonIdAuthor | Park, Jae-Yong | - |
dc.contributor.nonIdAuthor | Lee, Byungheon | - |
dc.identifier.citationVolume | 118 | - |
dc.identifier.citationNumber | 37 | - |
dc.identifier.citationTitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | TAMs | - |
dc.subject.keywordAuthor | GPCR | - |
dc.subject.keywordAuthor | Lactate | - |
dc.subject.keywordAuthor | Olfr78 | - |
dc.subject.keywordAuthor | OR51E2 | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | OLFACTORY RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DEPLETION | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | G2A | - |
dc.contributor.affiliatedAuthor | Vadevoo, Sir Murugan Poongkavithai | - |
dc.contributor.affiliatedAuthor | Gunassekaran, Gowri Rangaswarmy | - |
dc.contributor.affiliatedAuthor | Lee, ChaeEun | - |
dc.contributor.affiliatedAuthor | Lee, NaHye | - |
dc.contributor.affiliatedAuthor | Lee, Jiyoun | - |
dc.contributor.affiliatedAuthor | Chae, Sehyun | - |
dc.contributor.affiliatedAuthor | Park, Jae-Yong | - |
dc.contributor.affiliatedAuthor | Koo, JaeHyung | - |
dc.contributor.affiliatedAuthor | Lee, Byungheon | - |
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