Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, A Rang | - |
| dc.contributor.author | Baek, Su Min | - |
| dc.contributor.author | Lee, Seoung Woo | - |
| dc.contributor.author | Kim, Tae Un | - |
| dc.contributor.author | Han, Jee Eun | - |
| dc.contributor.author | Bae, Seul Gi | - |
| dc.contributor.author | Park, Sang Joon | - |
| dc.contributor.author | Kim, Tae Hwan | - |
| dc.contributor.author | Jeong, Kyu Shik | - |
| dc.contributor.author | Choi, Seong-Kyoon | - |
| dc.contributor.author | Park, Jin-Kyu | - |
| dc.date.accessioned | 2021-10-12T12:30:02Z | - |
| dc.date.available | 2021-10-12T12:30:02Z | - |
| dc.date.created | 2021-05-04 | - |
| dc.date.issued | 2021-05 | - |
| dc.identifier.citation | In Vivo, v.35, no.3, pp.1473 - 1483 | - |
| dc.identifier.issn | 0258-851X | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/15477 | - |
| dc.description.abstract | BACKGROUND/AIM: The pathological role of vascular endothelial growth factor receptor 2 (VEGFR-2) in chronic liver injury and liver regeneration is not fully understood. This study analysed the role of VEGFR-2 in liver fibrosis and its regeneration process. MATERIALS AND METHODS: We administered intraperitoneally 50 mg/kg to 300 mg/kg thioacetamide (TAA) to 9-week-old male mice for 17 weeks. We measured levels of VEGFR-2 protein and identified the location of cells that specifically express VEGFR-2. RESULTS: VEGFR-2 is rarely expressed in normal hepatocytes. However, high VEGFR-2 expression in liver sinusoidal endothelial cells was noted in the TAA group. Conversely, the group that experienced regeneration from liver fibrosis showed significantly higher VEGFR-2 expression in the nucleus of hepatocytes compared to the other groups. CONCLUSION: VEGFR-2 plays a pivotal role in the nucleus of hepatocytes during liver regeneration and VEGFR-2 may be closely related to cell division. Therefore, VEGFR-2 may be a new therapeutic target for liver regeneration. Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | - |
| dc.language | English | - |
| dc.publisher | International Institute of Anticancer Research | - |
| dc.title | Nuclear VEGFR-2 Expression of Hepatocytes Is Involved in Hepatocyte Proliferation and Liver Regeneration During Chronic Liver Injury | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.21873/invivo.12400 | - |
| dc.identifier.wosid | 000648900300017 | - |
| dc.identifier.scopusid | 2-s2.0-85105050999 | - |
| dc.type.local | Article(Overseas) | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.citation.publicationname | In Vivo | - |
| dc.contributor.nonIdAuthor | Lee, A Rang | - |
| dc.contributor.nonIdAuthor | Baek, Su Min | - |
| dc.contributor.nonIdAuthor | Lee, Seoung Woo | - |
| dc.contributor.nonIdAuthor | Kim, Tae Un | - |
| dc.contributor.nonIdAuthor | Han, Jee Eun | - |
| dc.contributor.nonIdAuthor | Bae, Seul Gi | - |
| dc.contributor.nonIdAuthor | Park, Sang Joon | - |
| dc.contributor.nonIdAuthor | Kim, Tae Hwan | - |
| dc.contributor.nonIdAuthor | Jeong, Kyu Shik | - |
| dc.contributor.nonIdAuthor | Park, Jin-Kyu | - |
| dc.identifier.citationVolume | 35 | - |
| dc.identifier.citationNumber | 3 | - |
| dc.identifier.citationStartPage | 1473 | - |
| dc.identifier.citationEndPage | 1483 | - |
| dc.identifier.citationTitle | In Vivo | - |
| dc.description.isOpenAccess | Y | - |
| dc.subject.keywordAuthor | VEGFR-2 | - |
| dc.subject.keywordAuthor | cell proliferation | - |
| dc.subject.keywordAuthor | liver regeneration | - |
| dc.subject.keywordAuthor | chronic liver disease | - |
| dc.subject.keywordAuthor | intracellular location | - |
| dc.subject.keywordPlus | HEPATIC STELLATE CELLS | - |
| dc.subject.keywordPlus | SINUSOIDAL ENDOTHELIAL-CELLS | - |
| dc.subject.keywordPlus | PLASMA-PROTEINS | - |
| dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
| dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
| dc.subject.keywordPlus | PHOSPHORYLATED KDR | - |
| dc.subject.keywordPlus | TARGETED DELIVERY | - |
| dc.subject.keywordPlus | SIZE | - |
| dc.subject.keywordPlus | CHEMISTRY | - |
| dc.subject.keywordPlus | MEMBRANE | - |
| dc.contributor.affiliatedAuthor | Lee, A Rang | - |
| dc.contributor.affiliatedAuthor | Baek, Su Min | - |
| dc.contributor.affiliatedAuthor | Lee, Seoung Woo | - |
| dc.contributor.affiliatedAuthor | Kim, Tae Un | - |
| dc.contributor.affiliatedAuthor | Han, Jee Eun | - |
| dc.contributor.affiliatedAuthor | Bae, Seul Gi | - |
| dc.contributor.affiliatedAuthor | Park, Sang Joon | - |
| dc.contributor.affiliatedAuthor | Kim, Tae Hwan | - |
| dc.contributor.affiliatedAuthor | Jeong, Kyu Shik | - |
| dc.contributor.affiliatedAuthor | Choi, Seong-Kyoon | - |
| dc.contributor.affiliatedAuthor | Park, Jin-Kyu | - |
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