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Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer

Title
Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer
Author(s)
Cho, YoungjunShin, HeejaePark, JaeuLee, SangHoon
DGIST Authors
Cho, YoungjunShin, HeejaePark, JaeuLee, SangHoon
Issued Date
2021-06
Type
Article
Author Keywords
neural interfaceshape memory polymerneuromodulationneural recodingneural stimulationbioelectronic medicine
Keywords
VAGUS NERVE-STIMULATIONDISEASE
ISSN
2072-666X
Abstract
Recently, methods for the treatment of chronic diseases and disorders through the modulation of peripheral and autonomic nerves have been proposed. To investigate various treatment methods and results, experiments are being conducted on animals such as rabbits and rat. However the diameter of the targeted nerves is small (several hundred μm) and it is difficult to modulate small nerves. Therefore, a neural interface that is stable, easy to implant into small nerves, and is biocompatible is required. Here, to develop an advanced neural interface, a thiol-ene/acrylate-based shape memory polymer (SMP) was fabricated with a double clip design. This micro-patterned design is able to be implanted on a small branch of the sciatic nerve, as well as the parasympathetic pelvic nerve, using the shape memory effect (SME) near body temperature. Additionally, the IrO2 coated neural interface was implanted on the common peroneal nerve in order to perform electrical stimulation and electroneurography (ENG) recording. The results demonstrate that the proposed neural interface can be used for the modulation of the peripheral nerve, including the autonomic nerve, towards bioelectronic medicine.
URI
http://hdl.handle.net/20.500.11750/15490
DOI
10.3390/mi12060720
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
  • 이상훈 Lee, Sanghoon
  • Research Interests Neural interface; Peripheral neuromodulation; Neuroprosthetics; Bioelectronics;
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2021_Advanced Neural interface toward bioelectronic medicine_SMP_Micromachines-12-00720.pdf

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Appears in Collections:
Department of Robotics and Mechatronics Engineering Neuro-Interfaced Robotics Lab 1. Journal Articles

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