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Preparation of multifunctional n-doped carbon quantum dots from citrus clementina peel: Investigating targeted pharmacological activities and the potential application for fe3+ sensing

Title
Preparation of multifunctional n-doped carbon quantum dots from citrus clementina peel: Investigating targeted pharmacological activities and the potential application for fe3+ sensing
Authors
Šafranko, SilvijaStanković, AnamarijaHajra, SugatoKim, Hoe JoonStrelec, IvicaDutour-Sikiric, MajaWeber, IgorBosnar, Maja HerakGrbčić, PetraPavelić, Sandra KraljevicSzechenyi, AleksandarMishra, Yogendra KumarJerković, IgorJokic, Stela
DGIST Authors
Šafranko, Silvija; Stanković, Anamarija; Hajra, Sugato; Kim, Hoe Joon; Strelec, Ivica; Dutour-Sikiric, Maja; Weber, Igor; Bosnar, Maja Herak; Grbčić, Petra; Pavelić, Sandra Kraljevic; Szechenyi, Aleksandar; Mishra, Yogendra Kumar; Jerković, Igor; Jokic, Stela
Issue Date
2021-08
Citation
Pharmaceuticals, 14(9)
Type
Article
Author Keywords
BiocompatibilityCarbon quantum dotsCitrus wasteFe3+ detectionN-doping
Keywords
GREEN SYNTHESISBIOMASSWASTECELLULOSEFACILEWATERIONS
ISSN
1424-8247
Abstract
Carbon quantum dots (CQDs) have recently emerged as innovative theranostic nanomaterials, enabling fast and effective diagnosis and treatment. In this study, a facile hydrothermal approach for N-doped biomass-derived CQDs preparation from Citrus clementina peel and amino acids glycine (Gly) and arginine (Arg) has been presented. The gradual increase in the N-dopant (amino acids) nitrogen content increased the quantum yield of synthesized CQDs. The prepared CQDs exhibited good biocompatibility, stability in aqueous, and high ionic strength media, similar optical properties, while differences were observed regarding the structural and chemical diversity, and biological and antioxidant activity. The antiproliferative effect of CQD@Gly against pancreatic cancer cell lines (CFPAC-1) was observed. At the same time, CQD@Arg has demonstrated the highest quantum yield and antioxidant activity by DPPH scavenging radical method of 81.39 ± 0.39% and has been further used for the ion sensing and cellular imaging of cancer cells. The obtained results have demonstrated selective response toward Fe3+ detection, with linear response ranging from 7.0 µmol dm−3 to 50.0 µmol dm−3 with R2 = 0.9931 and limit of detection (LOD) of 4.57 ± 0.27 µmol dm−3. This research could be a good example of sustainable biomass waste utilization with potential for biomedical analysis and ion sensing applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/15599
DOI
10.3390/ph14090857
Publisher
MDPI
Related Researcher
  • Author Kim, Hoe Joon Nano Materials and Devices Lab
  • Research Interests MEMS/NEMS; Micro/Nano Sensors; Piezoelectric Devices; Nanomaterials; Heat Transfer; Atomic Force Microscope
Files:
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Collection:
Department of Robotics and Mechatronics EngineeringNano Materials and Devices Lab1. Journal Articles


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