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DC Field Value Language Choi, Seung Hee - Hyeon, Do Young - Lee, Il Hwan - Park, Su Jin - Han, Seungmin - Lee, In Chul - Hwang, Daehee - Nam, Hong Gil - 2017-05-11T01:37:22Z - 2017-04-10 - 2014-11 -
dc.identifier.citation Scientific Reports, v.4 -
dc.identifier.issn 2045-2322 -
dc.identifier.uri -
dc.description.abstract Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12) in Arabidopsis cytokinin signaling using wild-type and single, double, and triple deletion mutants of the TFs. Comparative analysis of gene expression profiles obtained from Arabidopsis roots in wild-type and these mutants showed that duplication of ARR TFs systematically extended their transcriptional regulatory structures, leading to enhanced robustness and diversification in functions of target genes, as well as in regulation of cellular networks of target genes. Therefore, our results suggest that duplication of TFs contributes to robustness and diversification in functions of target genes by extending transcriptional regulatory structures. -
dc.language English -
dc.publisher Nature Publishing Group -
dc.title Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis -
dc.type Article -
dc.identifier.doi 10.1038/srep07197 -
dc.identifier.wosid 000346195800004 -
dc.identifier.scopusid 2-s2.0-84947460285 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Scientific Reports -
dc.contributor.nonIdAuthor Choi, Seung Hee -
dc.contributor.nonIdAuthor Hyeon, Do Young -
dc.contributor.nonIdAuthor Lee, Il Hwan -
dc.contributor.nonIdAuthor Park, Su Jin -
dc.contributor.nonIdAuthor Han, Seungmin -
dc.contributor.nonIdAuthor Lee, In Chul -
dc.identifier.citationVolume 4 -
dc.identifier.citationTitle Scientific Reports -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Choi, Seung Hee -
dc.contributor.affiliatedAuthor Hyeon, Do Young -
dc.contributor.affiliatedAuthor Lee, Il Hwan -
dc.contributor.affiliatedAuthor Park, Su Jin -
dc.contributor.affiliatedAuthor Han, Seungmin -
dc.contributor.affiliatedAuthor Lee, In Chul -
dc.contributor.affiliatedAuthor Hwang, Daehee -
dc.contributor.affiliatedAuthor Nam, Hong Gil -


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