Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Chul | - |
dc.contributor.author | Kim, Eunjoo | - |
dc.contributor.author | Lee, Se Geun | - |
dc.contributor.author | Lee, Sung Jun | - |
dc.contributor.author | Jeong, Sang Won | - |
dc.contributor.author | Lee, Young Jae | - |
dc.contributor.author | Kwon, Mi Kyung | - |
dc.contributor.author | Choi, Seong-Kyoon | - |
dc.contributor.author | Hwang, Jun Seong | - |
dc.contributor.author | Choi, Eun-Sook | - |
dc.date.accessioned | 2021-12-29T01:00:22Z | - |
dc.date.available | 2021-12-29T01:00:22Z | - |
dc.date.created | 2021-12-17 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | Polymers, v.13, no.24 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15983 | - |
dc.description.abstract | Reactive oxygen species (ROS)-responsive nanocarriers have received considerable research attention as putative cancer treatments because their tumor cell targets have high ROS levels. Here, we synthesized a miktoarm amphiphile of dithioketal-linked ditocopheryl polyethylene glycol (DTTP) by introducing ROS-cleavable thioketal groups as linkers between the hydrophilic and hydrophobic moieties. We used the product as a carrier for the controlled release of doxorubicin (DOX). DTTP has a critical micelle concentration (CMC) as low as 1.55 µg/mL (4.18 × 10−4 mM), encapsulation efficiency as high as 43.6 ± 0.23% and 14.6 nm particle size. The DTTP micelles were very responsive to ROS and released their DOX loads in a controlled manner. The tocopheryl derivates linked to DTTP generated ROS and added to the intracellular ROS in MCF-7 cancer cells but not in HEK-293 normal cells. In vitro cytotoxicity assays demonstrated that DOX-encapsulated DTTP micelles displayed strong antitumor activity but only slightly increased apoptosis in normal cells. This ROS-triggered, self-accelerating drug release device has high therapeutic efficacy and could be a practical new strategy for the clinical application of ROS-responsive drug delivery systems. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.title | Reactive Oxygen Species-Responsive Miktoarm Amphiphile for Triggered Intracellular Release of Anti-Cancer Therapeutics | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/polym13244418 | - |
dc.identifier.wosid | 000737465800001 | - |
dc.identifier.scopusid | 2-s2.0-85121655358 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Polymers | - |
dc.contributor.nonIdAuthor | Choi, Eun-Sook | - |
dc.identifier.citationVolume | 13 | - |
dc.identifier.citationNumber | 24 | - |
dc.identifier.citationTitle | Polymers | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | drug delivery system | - |
dc.subject.keywordAuthor | miktoarm amphiphile | - |
dc.subject.keywordAuthor | ROS-responsive | - |
dc.subject.keywordAuthor | tocopheryl derivate | - |
dc.subject.keywordAuthor | tumor therapy | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Chul | - |
dc.contributor.affiliatedAuthor | Kim, Eunjoo | - |
dc.contributor.affiliatedAuthor | Lee, Se Geun | - |
dc.contributor.affiliatedAuthor | Lee, Sung Jun | - |
dc.contributor.affiliatedAuthor | Jeong, Sang Won | - |
dc.contributor.affiliatedAuthor | Lee, Young Jae | - |
dc.contributor.affiliatedAuthor | Kwon, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Seong-Kyoon | - |
dc.contributor.affiliatedAuthor | Hwang, Jun Seong | - |
dc.contributor.affiliatedAuthor | Choi, Eun-Sook | - |