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Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review

Title
Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review
Authors
Cho, Hee JinKoo, JaeHyung
DGIST Authors
Cho, Hee Jin; Koo, JaeHyung
Issue Date
2021-12
Citation
BMB Reports, 54(12), 601-607
Type
Article
Author Keywords
GliomaGPCROdorant receptorOR51E1OR51E2
Keywords
OLFACTORY RECEPTORSPHYLOGENETIC ANALYSISREVEALSEXPRESSIONDYSREGULATIONLANDSCAPE
ISSN
1976-6696
Abstract
Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs). OR expression outside of the nose has functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers. Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve clinical outcomes. Here, we outlined the expression of brain ORs and investigated OR expression levels in glioma. Although most ORs were not ubiquitously expressed in gliomas, a subset of ORs displayed glioma subtype-specific expression. Moreover, through systematic survival analysis on OR genes, OR51E1 (mouse Olfr558) was identified as a potential biomarker of unfavorable overall survival, and OR2C1 (mouse Olfr15) was identified as a potential biomarker of favorable overall survival in isocitrate dehydrogenase (IDH) wild-type glioma. In addition to transcriptomic analysis, mutational profiles revealed that somatic mutations in OR genes were detected in > 60% of glioma samples. OR5D18 (mouse Olfr1155) was the most frequently mutated OR gene, and OR5AR1 (mouse Olfr1019) showed IDH wild-type-specific mutation. Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma, we suggest that ORs are potential biomarkers and therapeutic targets for glioma. © Korean Society for Biochemistry and Molecular Biology. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/16051
DOI
10.5483/BMBRep.2021.54.12.165
Publisher
생화학분자생물학회
Related Researcher
  • Author Koo, JaeHyung Brain-Immune Axis Laboratory
  • Research Interests 장내미생물/감염균 유래 대사체를 통한 신경염증, 알츠하이머병, 우울증, 당뇨/비만, 대사체/수용체 상호작용에 의한 대사연구
Files:
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Collection:
Department of New BiologyBrain-Immune Axis Laboratory1. Journal Articles


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