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Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissues

Title
Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissues
Authors
Kim, J.Y.Lim, HeejinMoon, DaeWon
DGIST Authors
Kim, J.Y.; Lim, Heejin; Moon, DaeWon
Issue Date
2022
Citation
Methods in molecular biology (Clifton, N.J.), 2437, 41-59
Type
Article
Author Keywords
Ambient mass spectrometric imagingAtmospheric pressure mass spectrometry imagingLaser ablationNanomaterialsSecondary ion mass spectrometrySingle-layer graphene
ISSN
1064-3745
Abstract
New methods to analyze cells and tissues in ambient condition without any harsh chemical fixation or physical freezing and drying are summarized in this report. The first approach, an atmospheric pressure mass spectrometry imaging method, is based on laser ablation in atmospheric pressure assisted by atmospheric plasma and nanomaterials such as nanoparticles and graphene to enhance laser ablation. The second one is based on secondary ion mass spectrometry (SIMS) imaging of live cells in solution capped with single-layer graphene to preserve intact and hydrated biological samples even under ultrahigh vacuum for SIMS bio-imaging in solution. © 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
URI
http://hdl.handle.net/20.500.11750/16094
DOI
10.1007/978-1-0716-2030-4_3
Publisher
Humana Press, Inc.
Files:
There are no files associated with this item.
Collection:
Department of New BiologyETC1. Journal Articles


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