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Multimodal diffuse optical system integrating DSCA-NIRS and cSFDI for measuring tissue metabolism

Title
Multimodal diffuse optical system integrating DSCA-NIRS and cSFDI for measuring tissue metabolism
Authors
Chaebeom Yeo
DGIST Authors
Chaebeom Yeo; Cheol SongJae Youn Hwang
Advisor(s)
송철
Co-Advisor(s)
Jae Youn Hwang
Issue Date
2022
Available Date
2022-03-08
Degree Date
2022/02
Type
Thesis
Keywords
Tissue metabolic rate of oxygen consumption, Coherent spatial frequency domain imaging, Diffuse speckle contrast analysis, Near-infrared spectroscopy, Multimodal diffuse optical system, Blood flow, Blood oxygen saturation. 조직 산소소모의 신진대사율, 가간섭 공간 주파수 도메인 이미징, 확산 스펙클 대비 분석기, 다중모드 확산 광학계 시스템, 근적외선 분광기, 혈류, 산소포화도.
Description
Tissue metabolic rate of oxygen consumption, Coherent spatial frequency domain imaging, Diffuse speckle contrast analysis, Near-infrared spectroscopy, Multimodal diffuse optical system, Blood flow, Blood oxygen saturation. 조직 산소소모의 신진대사율, 가간섭 공간 주파수 도메인 이미징, 확산 스펙클 대비 분석기, 다중모드 확산 광학계 시스템, 근적외선 분광기, 혈류, 산소포화도.
Table Of Contents
I. INTRODUCTION 1 II. THEORY AND PRINCIPLE 4 2.1 Diffuse Speckle Contrast Analysis (DSCA) 4 2.2 Near-infrared Spectroscopy (NIRS) 8 2.3 Combined DSCA and NIRS (DSCA-NIRS) 13 2.4 Spatial Frequency Domain Imaging (SFDI) 15 2.5 Coherent SFDI (cSFDI) 20 III. DESIGN AND IMPLEMENTATION 21 3.1 Design Goals 21 3.1.1 Wavelength Choice 21 3.1.2 Detector Choice 22 3.1.3 FOV in cSFDI, S-D Separations in DSCA-NIRS, and Penetration Depths 22 3.1.4 Camera Exposure Time Control in DSCA-NIRS 23 3.2 System Hardware Design and Implementation 24 3.2.1 Multimodal Diffuse Optical System 24 3.2.2 A Probe of Multimodal Diffuse Optical System 27 3.3 System Software Design and Implementation 29 3.3.1 DSCA-NIRS 31 3.3.2 cSFDI 32 IV. SYSTEM EVALUATION 35 4.1 Homogeneous Phantom Experiment 35 4.1.1 Experiment Protocols 35 4.1.2 Results 36 4.2 Flow Phantom Experiment 38 4.2.1 1st Experiment Protocols and Results 38 4.2.2 2nd Experiment Protocols and Results 40 4.2.3 3rd Experiment Protocols and Results 42 4.3 Intralipid Hemoglobin Titration Experiment 47 4.3.1 Experiment Protocols 47 4.3.2 Results 48 4.4 Yeast-Hemoglobin Experiment 49 4.4.1 Experiment Protocols 49 4.4.2 Results 49 V. EXPERIMENT AND RESULTS 51 5.1 in-vivo Experiment 51 5.2 Representative Results 53 5.2.1 Representative Results from DSCA-NIRS 53 5.2.2 Representative Results from cSFDI 55 5.3 Statistical Results 58 5.3.1 Changes of relative tMRO2 measured by cSFDI and DSCA-NIRS 58 5.3.2 Changes of StO2 measured by cSFDI, LBOM, and DSCA-NIRS 59 VI. DISCUSSION AND CONCLUSION 62 APPENDEDICES 67 A.1 Optical Power Intensity Measurement 67 A.2 Signal-to-Crosstalk Ratio 68 A.3 Inverse-Adding Doubling 70 A.4 Raw Data measured from LBOM during Yeast-Hemoglobin Experiment 71 A.5 Signal-to-Noise Ratio Estimation 72 A.6 Quantum Efficiency of a Camera used in This Work 73 REFERENCES 74 국문 요약문 80
URI
http://dgist.dcollection.net/common/orgView/200000596669
http://hdl.handle.net/20.500.11750/16305
DOI
10.22677/thesis.200000596669
Degree
Doctor
Department
Robotics Engineering
University
DGIST
Related Researcher
  • Author Song, Cheol Intelligent Bio-OptoMechatronics Lab
  • Research Interests Handheld medical robotics; Smart robotic microsurgery; Smart neuro-rehabilitation; Bio-photonic sensing and imaging
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringThesesPh.D.


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