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Single-cell RNA sequencing reveals that Baf contributes to neural progenitor competence of Drosophila nervous system in a lineage-specific manner

Title
Single-cell RNA sequencing reveals that Baf contributes to neural progenitor competence of Drosophila nervous system in a lineage-specific manner
Translated Title
단일 세포 전사체 분석을 통한 Drosophila 신경계 내에서 Baf가 계통특이적 신경전구세포 분화능에 미치는 영향에 관한 연구
Authors
Dong Gon Cha
DGIST Authors
Dong Gon Cha; Jong Kyoung Kim; June M. Kwak
Advisor(s)
김종경
Co-Advisor(s)
June M. Kwak
Issue Date
2022
Available Date
2022-03-08
Degree Date
2022/02
Type
Thesis
Keywords
scRNA-seq, Barrier to autointegration factor (Baf), chromatin organization, neural progenitor competence, neurodevelopment
Description
scRNA-seq, Barrier to autointegration factor (Baf), chromatin organization, neural progenitor competence, neurodevelopment
Table Of Contents
I. Introduction 1 II. Preliminaries 3 2.1 Drosophila neuroblasts with Baf knockdown shows abnormal chromatin organization and formation of neuroblast clones 3 2.2 pan-neuronal knockdown of Baf induces marked reduction of excitatory neurons at the adult stage 3 2.3 Neuronal knockdown of Baf induces behavioral abnormalities at the adult stage 4 III. Results 5 3.1 scRNA-seq identifies cell types in neuronal lineage from control and Baf KD Drosophila 5 3.2 Baf knockdown induces transcriptional changes in Type I neuroblasts 7 3.3 Type I neuroblast-specific neurodevelopment is impaired by Baf knockdown 8 IV. Discussion 11 V. Materials and methods 13 5.1 Sample preparation for single-cell sequencing 13 5.2 scRNA-seq data preprocessing 13 5.3 scRNA-seq data analysis 14 References 15 요약문 20
URI
http://dgist.dcollection.net/common/orgView/200000591876
http://hdl.handle.net/20.500.11750/16326
DOI
10.22677/thesis.200000591876
Degree
Master
Department
New Biology
University
DGIST
Related Researcher
  • Author Kwak, June Myoung Lab of Cell Signaling and Development
  • Research Interests Calcium Signaling; ABA;ROS Signaling; plant development; Development of Abscission; Culluar Features; Signaling network; Environmental Regulation
Files:
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Collection:
Department of New BiologyThesesMaster


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