Strategy for identifying organophosphate adducts in biological samples using high resolution mass spectrometry
- Title
- Strategy for identifying organophosphate adducts in biological samples using high resolution mass spectrometry
- Author(s)
- Jun Hyung Lee
- DGIST Authors
- Jun Hyung Lee ; Min-Sik Kim ; Jin Hae Kim
- Advisor
- 김민식
- Co-Advisor(s)
- Jin Hae Kim
- Issued Date
- 2022
- Awarded Date
- 2022/02
- Type
- Thesis
- Description
- Mass spectrometry, Human Serum Albumin, Organophosphate, Nuerotoxicity, Open-search
- Table Of Contents
-
Ⅰ. INTRODUCTION 1
1.1 Incidents of nerve agent exposure 1
1.2 Organophosphate 1
1.3 Etiology 2
1.4 Pathophysiology & Toxicokinetics 2
1.5 Detection method for Organophosphate 2
1.6 Human Serum Albumin (HSA) 3
1.7 Proteomics 3
Ⅱ. Material and Method 4
2.1 Materials 4
2.2 Sample preparation method 5
2.3 Q-Exactive LC-MS-MS analysis 5
2.4 Data analysis 5
2.5 Crystal structure of human albumin visualization 6
Ⅲ. Result & Discussion 6
3.1 OP-HSA modification site detection 6
3.2 Characteristic of potential binding affinity at OP-modification site 7
3.3 Y263 site have a immonium ion-fragmentation characteristic 7
3.4 IM-based search method 8
3.5 Discussion 8
Reference 19
요약문 21
- URI
-
http://dgist.dcollection.net/common/orgView/200000596601
http://hdl.handle.net/20.500.11750/16327
- Degree
- Master
- Department
- New Biology
- Publisher
- DGIST
- Related Researcher
-
-
Kim, Min-Sik
- Research Interests Cancer Proteogenomics; Biomarker Discovery; Integrative Multi-Omics
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- Files in This Item:
-
There are no files associated with this item.
- Appears in Collections:
- Department of New Biology Theses Master
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