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dc.contributor.advisor 김민식 -
dc.contributor.author Jun Hyung Lee -
dc.date.accessioned 2022-03-07T16:00:40Z -
dc.date.available 2022-03-07T16:00:40Z -
dc.date.issued 2022 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000596601 en_US
dc.identifier.uri http://hdl.handle.net/20.500.11750/16327 -
dc.description Mass spectrometry, Human Serum Albumin, Organophosphate, Nuerotoxicity, Open-search -
dc.description.statementofresponsibility N -
dc.description.tableofcontents Ⅰ. INTRODUCTION 1
1.1 Incidents of nerve agent exposure 1
1.2 Organophosphate 1
1.3 Etiology 2
1.4 Pathophysiology & Toxicokinetics 2
1.5 Detection method for Organophosphate 2
1.6 Human Serum Albumin (HSA) 3
1.7 Proteomics 3
Ⅱ. Material and Method 4
2.1 Materials 4
2.2 Sample preparation method 5
2.3 Q-Exactive LC-MS-MS analysis 5
2.4 Data analysis 5
2.5 Crystal structure of human albumin visualization 6
Ⅲ. Result & Discussion 6
3.1 OP-HSA modification site detection 6
3.2 Characteristic of potential binding affinity at OP-modification site 7
3.3 Y263 site have a immonium ion-fragmentation characteristic 7
3.4 IM-based search method 8
3.5 Discussion 8
Reference 19
요약문 21
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dc.format.extent 21 -
dc.language eng -
dc.publisher DGIST -
dc.subject Mass spectrometry, Human Serum Albumin, Organophosphate, Nuerotoxicity, Open-search -
dc.title Strategy for identifying organophosphate adducts in biological samples using high resolution mass spectrometry -
dc.type Thesis -
dc.identifier.doi 10.22677/thesis.200000596601 -
dc.description.degree Master -
dc.contributor.department New Biology -
dc.contributor.coadvisor Jin Hae Kim -
dc.date.awarded 2022/02 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.NM 이76 202202 -
dc.date.accepted 1/21/22 -
dc.contributor.alternativeDepartment 뉴바이올로지전공 -
dc.embargo.liftdate 20270228 -
dc.contributor.affiliatedAuthor Jun Hyung Lee -
dc.contributor.affiliatedAuthor Min-Sik Kim -
dc.contributor.affiliatedAuthor Jin Hae Kim -
dc.contributor.alternativeName 이준형 -
dc.contributor.alternativeName Min-Sik Kim -
dc.contributor.alternativeName 김진해 -
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