PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells

Abstract

The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells. © 2016 Elsevier Ltd