PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells
- Title
- PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells
- DGIST Authors
- Suh, BC[Suh, Byung-Chang] ; Yeon, JH[Yeon, Jun-Hee] ; Park, CG[Park, Cheon-Gyu]
- Issued Date
- 2016-07-21
- Type
- Article
- Article Type
- Short Survey; Editorial Material
- ISSN
- 2451-9448
- Abstract
- The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells. © 2016 Elsevier Ltd
- Publisher
- Cell Press
- Related Researcher
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Suh, Byung-Chang
- Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
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- Appears in Collections:
- Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles
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