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PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells
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- Title
- PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells
- DGIST Authors
- Suh, BC[Suh, Byung-Chang] ; Yeon, JH[Yeon, Jun-Hee] ; Park, CG[Park, Cheon-Gyu]
- Issued Date
- 2016-07-21
- Citation
- Suh, BC[Suh, Byung-Chang]. (2016-07-21). PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells. doi: 10.1016/j.chembiol.2016.07.001
- Type
- Article
- Article Type
- Short Survey; Editorial Material
- ISSN
- 2451-9448
- Abstract
-
The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells. © 2016 Elsevier Ltd
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- Publisher
- Cell Press
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