DGIST Scholar: PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells

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Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles

PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells

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Title: PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells

DGIST Authors: Suh, BC[Suh, Byung-Chang] ; Yeon, JH[Yeon, Jun-Hee] ; Park, CG[Park, Cheon-Gyu]

Issued Date: 2016-07-21

Citation: Suh, BC[Suh, Byung-Chang]. (2016-07-21). PI(4,5)P-2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in beta Cells. doi: 10.1016/j.chembiol.2016.07.001

Type: Article

Article Type: Short Survey; Editorial Material

ISSN: 2451-9448

Abstract: The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells. © 2016 Elsevier Ltd

URI: http://hdl.handle.net/20.500.11750/1634

DOI: 10.1016/j.chembiol.2016.07.001

Publisher: Cell Press

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