Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Jun Hyung | - |
dc.contributor.author | Jang, Wooyoung Eric | - |
dc.contributor.author | Park, Jihwan | - |
dc.contributor.author | Mohammad, Hazara Begum | - |
dc.contributor.author | Lee, Jin-Young | - |
dc.contributor.author | Jeong, Woo-Hyeon | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.date.accessioned | 2022-04-11T05:30:12Z | - |
dc.date.available | 2022-04-11T05:30:12Z | - |
dc.date.created | 2022-01-28 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16453 | - |
dc.description.abstract | Organophosphate (OP) compounds exhibit neurotoxicity by binding to serine residues of acetylcholinesterase (AChE) in the cholinergic nervous system and subsequently lead to the accumulation of acetylcholine in neuromuscular junctions of synapses. AChE capable of hydrolyzing choline esters is known to be inhibited in patients with nerve agents poisoning. Since OP is known to be transported by covalent bonding to human serum albumin (HSA), OP-HSA adducts are considered potential diagnostic markers for OP exposures. In this study, HSA modification sites by OP or OP-like compounds such as V-type (VX) and Novichok-type (A234), insecticide (DFP), and serine protease inhibitor (PMSF) were studied using liquid chromatography-high-resolution tandem mass spectrometry. As a result, we have discovered a novel OP-HSA modification site, Y341. © 2022 Korean Chemical Society, Seoul & Wiley-VCH GmbH | - |
dc.language | English | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Identification of organophosphate modifications by high-resolution mass spectrometry | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bkcs.12478 | - |
dc.identifier.wosid | 000744325500001 | - |
dc.identifier.scopusid | 2-s2.0-85122970787 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.43, no.3, pp.444 - 449 | - |
dc.identifier.kciid | ART002822314 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | nuerotoxicity | - |
dc.subject.keywordAuthor | organophosphate | - |
dc.subject.keywordAuthor | protein modification | - |
dc.subject.keywordAuthor | human plasma | - |
dc.subject.keywordAuthor | mass spectrometry | - |
dc.subject.keywordPlus | HUMAN SERUM-ALBUMIN | - |
dc.subject.keywordPlus | NERVE AGENTS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | ADDUCTS | - |
dc.subject.keywordPlus | PESTICIDES | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.citation.endPage | 449 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 444 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 43 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.type.docType | Article | - |
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