Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hwang, Wooseon | - |
dc.contributor.author | Artan, Murat | - |
dc.contributor.author | Seo, Mihwa | - |
dc.contributor.author | Lee, Dongyeop | - |
dc.contributor.author | Nam, Hong Gil | - |
dc.contributor.author | Lee, Seung-Jae V. | - |
dc.date.available | 2017-05-11T01:46:59Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/1652 | - |
dc.description.abstract | The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF-1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that elc-1 RNA interference increased lifespan and protein homeostasis by upregulating HIF-1. The roles of elongin C and HIF-1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF-1 in complex metazoans. © 2015 The Anatomical Society and John Wiley & Sons Ltd. | - |
dc.publisher | Wiley Blackwell | - |
dc.title | Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/acel.12390 | - |
dc.identifier.scopusid | 2-s2.0-84954404673 | - |
dc.identifier.bibliographicCitation | Aging Cell, v.14, no.6, pp.995 - 1002 | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | elc-1 | - |
dc.subject.keywordAuthor | hypoxia-inducible factor 1 | - |
dc.subject.keywordAuthor | protein homeostasis | - |
dc.subject.keywordPlus | Aging | - |
dc.subject.keywordPlus | Amino ACID Sequence | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | C. Elegans | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | Caenorhabditis Elegans | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | elc-1 | - |
dc.subject.keywordPlus | ELONGATION | - |
dc.subject.keywordPlus | Elongin C | - |
dc.subject.keywordPlus | Genetic Association | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR | - |
dc.subject.keywordPlus | Hypoxia-Inducible Factor-1 | - |
dc.subject.keywordPlus | INTEGRATIVE ANALYSIS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | Lifespan | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | Mitochondrial Gene | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Priority Journal | - |
dc.subject.keywordPlus | Protein Degradation | - |
dc.subject.keywordPlus | Protein Homeostasis | - |
dc.subject.keywordPlus | Protein Synthesis Inhibition | - |
dc.subject.keywordPlus | Regulatory Mechanism | - |
dc.subject.keywordPlus | RESPIRATION | - |
dc.subject.keywordPlus | RNA Interference | - |
dc.subject.keywordPlus | Transcription Elongation Factor | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR-SIII | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | Up-Regulation | - |
dc.citation.endPage | 1002 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 995 | - |
dc.citation.title | Aging Cell | - |
dc.citation.volume | 14 | - |
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