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dc.contributor.author Seo, Mihwa -
dc.contributor.author Seo, Keunhee -
dc.contributor.author Hwang, Wooseon -
dc.contributor.author Koo, Hee Jung -
dc.contributor.author Hahm, Jeong-Hoon -
dc.contributor.author Yang, Jae-Seong -
dc.contributor.author Han, Seong Kyu -
dc.contributor.author Hwang, Daehee -
dc.contributor.author Kim, Sanguk -
dc.contributor.author Jang, Sung Key -
dc.contributor.author Lee, Yoontae -
dc.contributor.author Nam, Hong Gil -
dc.contributor.author Lee, Seung-Jae V. -
dc.date.available 2017-05-11T01:47:21Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-08-04 -
dc.identifier.issn 0027-8424 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/1659 -
dc.description.abstract The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. We find that HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) and is sufficient for extending lifespan. We further show that the expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes. Thus, the RNA helicase HEL-1 appears to promote longevity in response to decreased IIS as a transcription coregulator of DAF-16. Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans. -
dc.publisher National Academy of Sciences -
dc.title RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans -
dc.type Article -
dc.identifier.doi 10.1073/pnas.1505451112 -
dc.identifier.scopusid 2-s2.0-84938629424 -
dc.identifier.bibliographicCitation Proceedings of the National Academy of Sciences of the United States of America, v.112, no.31, pp.E4246 - E4255 -
dc.subject.keywordAuthor C. elegans -
dc.subject.keywordAuthor aging -
dc.subject.keywordAuthor FOXO -
dc.subject.keywordAuthor insulin/IGF-1 -
dc.subject.keywordAuthor RNA helicase -
dc.subject.keywordPlus Aging -
dc.subject.keywordPlus Animal -
dc.subject.keywordPlus Animals -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus Base Sequence -
dc.subject.keywordPlus BINDING-PROTEIN -
dc.subject.keywordPlus C-ELEGANS -
dc.subject.keywordPlus C. Elegans -
dc.subject.keywordPlus Caenorhabditis Elegans -
dc.subject.keywordPlus Caenorhabditis Elegans Protein -
dc.subject.keywordPlus Caenorhabditis Elegans Proteins -
dc.subject.keywordPlus Controlled Study -
dc.subject.keywordPlus DAF-16 Protein, C Elegans -
dc.subject.keywordPlus DAF-2 Protein, C Elegans -
dc.subject.keywordPlus DATA INTEGRATION METHODOLOGY -
dc.subject.keywordPlus Dead Box Protein -
dc.subject.keywordPlus Enzymology -
dc.subject.keywordPlus EXPORT FACTOR -
dc.subject.keywordPlus Forkhead Transcription Factor -
dc.subject.keywordPlus Forkhead Transcription Factors -
dc.subject.keywordPlus FOXO -
dc.subject.keywordPlus Gene -
dc.subject.keywordPlus GENE-EXPRESSION -
dc.subject.keywordPlus Gene Expression Profiling -
dc.subject.keywordPlus Gene Expression Regulation -
dc.subject.keywordPlus Gene Expression Regulation, Developmental -
dc.subject.keywordPlus Gene Knockdown Techniques -
dc.subject.keywordPlus Gene Ontology -
dc.subject.keywordPlus Gene Silencing -
dc.subject.keywordPlus Genes, Helminth -
dc.subject.keywordPlus Genetics -
dc.subject.keywordPlus Heat Stress -
dc.subject.keywordPlus HEL-1 Protein, C Elegans -
dc.subject.keywordPlus Helicase 1 -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus Insulin -
dc.subject.keywordPlus Insulin-Like Growth Factor I -
dc.subject.keywordPlus Insulin Receptor -
dc.subject.keywordPlus Insulin/IGF-1 -
dc.subject.keywordPlus INTESTINE -
dc.subject.keywordPlus Intestines -
dc.subject.keywordPlus LIFE-SPAN -
dc.subject.keywordPlus Lifespan -
dc.subject.keywordPlus LONGEVITY -
dc.subject.keywordPlus Mammalia -
dc.subject.keywordPlus Messenger RNA -
dc.subject.keywordPlus Metabolism -
dc.subject.keywordPlus Mitochondrial Respiration -
dc.subject.keywordPlus Molecular Genetics -
dc.subject.keywordPlus Molecular Sequence Data -
dc.subject.keywordPlus Mutation -
dc.subject.keywordPlus Nerve Cell -
dc.subject.keywordPlus Neurons -
dc.subject.keywordPlus Nonhuman -
dc.subject.keywordPlus Nucleotide Sequence -
dc.subject.keywordPlus OXIDATIVE STRESS -
dc.subject.keywordPlus Phenotype -
dc.subject.keywordPlus Physiology -
dc.subject.keywordPlus Priority Journal -
dc.subject.keywordPlus Progeny -
dc.subject.keywordPlus Protein Binding -
dc.subject.keywordPlus Pseudomonas Aeruginosa -
dc.subject.keywordPlus Receptor, Insulin -
dc.subject.keywordPlus Regulatory Mechanism -
dc.subject.keywordPlus Reproduction -
dc.subject.keywordPlus RNA Helicase -
dc.subject.keywordPlus RNA Helicases -
dc.subject.keywordPlus RNA Interference -
dc.subject.keywordPlus RNA Sequence -
dc.subject.keywordPlus RNA, Messenger -
dc.subject.keywordPlus ROLES -
dc.subject.keywordPlus Sequence Analysis -
dc.subject.keywordPlus Sequence Analysis, RNA -
dc.subject.keywordPlus Signal Transduction -
dc.subject.keywordPlus Somatomedin -
dc.subject.keywordPlus Somatomedin 1 -
dc.subject.keywordPlus Somatomedin C -
dc.subject.keywordPlus Systems Biology -
dc.subject.keywordPlus Transcription Factor DAF 16 -
dc.subject.keywordPlus Transcription Factor FOXO -
dc.subject.keywordPlus Transgene -
dc.subject.keywordPlus Unclassified Drug -
dc.subject.keywordPlus Up-Regulation -
dc.subject.keywordPlus YEAST -
dc.citation.endPage E4255 -
dc.citation.number 31 -
dc.citation.startPage E4246 -
dc.citation.title Proceedings of the National Academy of Sciences of the United States of America -
dc.citation.volume 112 -

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