Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유성운 | - |
| dc.contributor.author | Youngjin Park | - |
| dc.date.accessioned | 2022-07-07T02:29:01Z | - |
| dc.date.available | 2022-07-07T02:29:01Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000361998 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16652 | - |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 Ⅱ. Material and Methods 7 2.1 Animals 7 2.2 Cell culture 7 2.3 Reagents and antibodies 9 2.4 Cell death assay 9 2.5 Enzyme-linked immunosorbent assay 10 2.6 Quantitative RT-PCR 10 2.7 Western blot 12 2.8 Microglial transduction 12 2.9 Measurement of Aβ uptake and degradation 13 2.8 Statistical analysis 14 Ⅲ. Results 15 3.1 Compound D reduces neuroinflammation through recovery of REV-ERBα level in KI/+ microglia 15 3.2 Compound D regulates clock genes and clock-controlled cytokines in KI/+ microglia 21 3.3 Compound D reduces neuroinflammation in KI/+ macrophages 25 3.4 Compound D induces autophagy and Aβ clearance in microglia 29 3.5 Compound D recovers autophagy in LPS treated microglia 33 Ⅳ. Discussion 38 Ⅴ. Reference 43 Abstract in Korean 47 |
- |
| dc.format.extent | 47 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | Alzheimer’s disease (AD), microglia, neuroinflammation, autophagy, Anti-inflammatory or anti-AD drug screening, 알츠하이머병, 미세아교세포, 신경염증, 자가포식작용, 항 염증 또는 항 알츠하이머 약물 스크리닝 | - |
| dc.title | Attenuation of neuroinflammation by an antiarrhythmic drug through reduction of IL-6 in Presenilin 2 N141I knock-in Alzheimer disease model | - |
| dc.title.alternative | 가족성 알츠하이머 질병 마우스 모델에서 미세아교세포에 대한 compound D의 항염증효과 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000361998 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Young-sam Lee | - |
| dc.date.awarded | 2021/02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 박64 202102 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2026-02-28 | - |
| dc.contributor.affiliatedAuthor | Youngjin Park | - |
| dc.contributor.affiliatedAuthor | Seong-Woon Yu | - |
| dc.contributor.affiliatedAuthor | Young-sam Lee | - |
| dc.contributor.alternativeName | 박영진 | - |
| dc.contributor.alternativeName | Seong-Woon Yu | - |
| dc.contributor.alternativeName | 이영삼 | - |
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