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Development of the magnetically powered untethered microrobots for targeted cell therapy

Title
Development of the magnetically powered untethered microrobots for targeted cell therapy
Translated Title
최초침습 정밀 세포치료를 위한 자기장 구동형 마이크로로봇 개발
Authors
Sungwoong Jeon
DGIST Authors
Sungwoong Jeon; Hongsoo ChoiJin-young Kim
Advisor(s)
최홍수
Co-Advisor(s)
Jin-young Kim
Issue Date
2021
Available Date
2022-07-07
Degree Date
2021/02
Type
Thesis
Keywords
Microrobot, Magnetic actuation, Stem cell therapy, Targeted therapy, MEMS
Table Of Contents
1. Introduction 1 1.1 Background 1 1.2 Research trends 4 1.2.1 Microrobots for targeted therapy 4 1.2.2 Microrobots for stem cell therapy 8 1.3 Objectives of research 11 2. Magnetically actuated microrobots as a platform for stem cell transplantation 15 2.1 Introduction 15 2.2 Results 18 2.2.1 Fabrication and characterization of the microrobots 18 2.2.2 Hippocampal NSC culture and delivery in vitro 22 2.2.3 Ex vivo manipulation of the microrobots 29 2.2.4 In vivo stem cell transportation using the microrobots 31 2.3 Discussion & conclusion 33 2.4 Materials & method 35 3. Magnetically actuated SiCN-based ceramic microrobot for cell delivery 51 3.1 Introduction 51 3.2 Result & discussion 54 3.3 Conclusion 66 3.4 Materials & methods 67 4. Magnetically powered GelMA-based biodegradable microrobot for localized stem cell delivery 73 4.1 Introduction 73 4.2 Result & discussion 76 4.3 Conclusion 86 4.4 Materials & methods 87 5. Intranasal delivery of a stem cell microrobot bypassing the blood-brain barrier 93 5.1 Introduction 93 5.2 Result & Discussion 96 5.3 Conclusion 109 5.4 Materials & methods 111 6. Conclusions & Future work 119 6.1 Conclusions 119 6.2 Future work 121 6.2.1 Magnetically driven piezoelectric microrobot (mpMR) for cell stimulation 121 6.2.2 Fabrication and characterization of the mpMRs 123 6.2.3 Applications of the mpMRs 124 ACKNOWLEDGMENT 126 PUBLICATION LIST 129 REFERENCE 133 요 약 문 145 APPENDIX 148
URI
http://dgist.dcollection.net/common/orgView/200000363762
http://hdl.handle.net/20.500.11750/16681
DOI
10.22677/thesis.200000363762
Degree
Doctor
Department
Robotics Engineering
University
DGIST
Related Researcher
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringThesesPh.D.


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