DGIST Scholar: Development of the magnetically powered untethered microrobots for targeted cell therapy

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Development of the magnetically powered untethered microrobots for targeted cell therapy

Title: Development of the magnetically powered untethered microrobots for targeted cell therapy

Keywords: Microrobot, Magnetic actuation, Stem cell therapy, Targeted therapy, MEMS

Table Of Contents: 1. Introduction 1 1.1 Background 1 1.2 Research trends 4 1.2.1 Microrobots for targeted therapy 4 1.2.2 Microrobots for stem cell therapy 8 1.3 Objectives of research 11 2. Magnetically actuated microrobots as a platform for stem cell transplantation 15 2.1 Introduction 15 2.2 Results 18 2.2.1 Fabrication and characterization of the microrobots 18 2.2.2 Hippocampal NSC culture and delivery in vitro 22 2.2.3 Ex vivo manipulation of the microrobots 29 2.2.4 In vivo stem cell transportation using the microrobots 31 2.3 Discussion & conclusion 33 2.4 Materials & method 35 3. Magnetically actuated SiCN-based ceramic microrobot for cell delivery 51 3.1 Introduction 51 3.2 Result & discussion 54 3.3 Conclusion 66 3.4 Materials & methods 67 4. Magnetically powered GelMA-based biodegradable microrobot for localized stem cell delivery 73 4.1 Introduction 73 4.2 Result & discussion 76 4.3 Conclusion 86 4.4 Materials & methods 87 5. Intranasal delivery of a stem cell microrobot bypassing the blood-brain barrier 93 5.1 Introduction 93 5.2 Result & Discussion 96 5.3 Conclusion 109 5.4 Materials & methods 111 6. Conclusions & Future work 119 6.1 Conclusions 119 6.2 Future work 121 6.2.1 Magnetically driven piezoelectric microrobot (mpMR) for cell stimulation 121 6.2.2 Fabrication and characterization of the mpMRs 123 6.2.3 Applications of the mpMRs 124 ACKNOWLEDGMENT 126 PUBLICATION LIST 129 REFERENCE 133 요 약 문 145 APPENDIX 148