Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 문제일 | - |
| dc.contributor.author | Yeri Kim | - |
| dc.date.accessioned | 2022-07-07T02:29:15Z | - |
| dc.date.available | 2022-07-07T02:29:15Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000364571 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16700 | - |
| dc.description.abstract | The posterior parietal cortex (PPC) together with the prefrontal cortex (PFC) has been known as essential regions for cognitive functions such as attention, navigation, decision-making, as well as working memory (WM). Lesion of the PPC or the PFC leads to a significant WM im-pairment in various animals. Particularly, the critical function of the cholinergic innervation in the PFC has been demonstrated in chemically or genetically depleted animal models, yet the func-tion of acetylcholine in PPC has never been explored thoroughly. | - |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 1.1 Working memory 1 1.2 Acetylcholine in WM 1 1.3 Psychophysical experiments 2 Ⅱ. Materials and Method 3 2.1 Animals 3 2.2 Stereotaxic surgery 3 2.3 Two-alternative forced-choice task 3 2.4 Behavioral experiments 4 2.4.1 Pharmacological inactivation 4 2.4.2 Optogenetic inactivation 4 2.5 Ex vivo whole-cell recording 5 2.5.1 Sustained activity with drug application 5 2.5.2 Photoinhibition of the pyramidal neurons in the mPFC 2/3 layer 5 2.6 Data analysis and statistics 6 Ⅲ. Results 7 Ⅳ. Discussion 28 References 31 요약문 35 |
- |
| dc.format.extent | 35 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | Working-Memory, Medial prefrontal cortex, Posterior cingulate cortex, Acetylcholine, 전전두피질, 후두정피질, 아세틸콜린, 패치클램프, 광유전학 | - |
| dc.title | The role of acetylcholine in the mPFC and the PPC during working memory: The behavioral analysis of pharmacological and optogenetical manipulation of neural activity and cholinergic modulation | - |
| dc.title.alternative | 단기 기억에서 아세틸콜린의 역할: 약물 또는 광유전학을 이용한 활성 조절과 아세틸콜린 조절을 통한 행동학적 분석 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000364571 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Jong-Cheol Rah | - |
| dc.date.awarded | 2021/02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 김64 202102 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2023-02-28 | - |
| dc.contributor.affiliatedAuthor | Yeri Kim | - |
| dc.contributor.affiliatedAuthor | Cheil Moon | - |
| dc.contributor.affiliatedAuthor | Jong-Cheol Rah | - |
| dc.contributor.alternativeName | 김예리 | - |
| dc.contributor.alternativeName | Cheil Moon | - |
| dc.contributor.alternativeName | 라종철 | - |
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