Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김소희 | - |
| dc.contributor.author | Hee Won Seo | - |
| dc.date.accessioned | 2022-08-17T16:00:07Z | - |
| dc.date.available | 2022-08-17T16:00:07Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000627656 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16775 | - |
| dc.description | retinal prosthesis, subretinal implant, neural electrodes, 3D microelectrodes, transparent base | - |
| dc.description.abstract | - | |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | Chapter Ⅰ. Introduction 1 1. Background 2 1.1 Retinal disease 2 1.2 Visual prosthesis 4 2. Objective of research 13 3. References 15 Chapter Ⅱ. 3D microelectrodes with square arrangement 18 1. Introduction 19 2. Methods 23 2.1 Modeling and simulation to optimize the electrode geometry 23 2.2 Design and fabrication of the transparent 3D microelectrode array 28 2.2.1 Design of the microelectrodes 28 2.2.2 Fabrication of the microelectrodes 29 2.3 Electrochemical characterization 35 2.4 In-vitro experiment 36 2.4.1 Retina preparation 36 2.4.2 Multi-electrode recording system 39 2.4.3 Electrical stimulation 39 2.4.4 Data analysis 40 3. Results and discussion 42 3.1 Simulated results of the electrode designs 42 3.2 Fabrication results of the electrodes 45 3.3 Electrode impedance and cyclic voltammetry 47 3.4 In-vitro subretinal stimulation 49 4. Conclusion 54 5. References 55 Chapter Ⅲ. 3D microelectrodes with hexagonal arrangement 60 1. Introduction 61 2. Materials and methods 64 2.1 Design of subretinal electrode array 64 2.2 Generation of silicon pillars and transparent base 65 2.3 Generation of connection pads and parylene insulation 68 2.4 Electrochemical characterization 71 2.5 Material properties 72 2.6 Improved electrodes and accelerated aging test 73 2.7 In-vitro experiment 75 3. Results and discussion 78 3.1 Fabrication results of the electrodes 78 3.2 Electrode impedance and cyclic voltammetry 84 3.3 Properties of the fabricated electrodes 87 3.3.1 Transmittance and reflectance of materials 87 3.3.2 Long-term EIS results and CSC 90 3.4 In-vitro subretinal stimulation 92 3.4.1 Single stimulation 92 3.4.2 Stimulation with the opposite current 94 4. Conclusion 105 5. References 107 Chapter Ⅳ. Biocompatibility evaluation of 3D subretinal electrodes 111 1. Introduction 112 2. Materials and methods 115 2.1 Subretinal implants 115 2.2 Animals and surgical procedure 118 2.3 Fundus infrared reflectance and SD-OCT 120 2.4 Immunohistochemical examination (tissue clearing method) 124 3. Results 126 3.1 SD-OCT imaging and TRL thicknesses 126 3.2 Immunohistochemical analysis 135 4. Discussion 138 5. Conclusion 147 6. References 148 Chapter Ⅴ. Conclusion and future direction 152 1. Conclusion 153 2. Future direction 158 3. References 160 Appendix 162 요약문 169 |
- |
| dc.format.extent | 170 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | retinal prosthesis, subretinal implant, neural electrodes, 3D microelectrodes, transparent base | - |
| dc.title | Three-dimensional microelectrodes for subretinal stimulation | - |
| dc.title.alternative | 망막하 자극을 위한 3차원 형태의 미세전극들 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000627656 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | Department of Robotics and Mechatronics Engineering | - |
| dc.contributor.coadvisor | Han Kyoung Choe | - |
| dc.date.awarded | 2022/08 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.RD 서97 202208 | - |
| dc.date.accepted | 8/11/22 | - |
| dc.contributor.alternativeDepartment | 로봇및기계전자공학과 | - |
| dc.embargo.liftdate | 2023-08-31 | - |
| dc.contributor.affiliatedAuthor | Hee Won Seo | - |
| dc.contributor.affiliatedAuthor | Sohee Kim | - |
| dc.contributor.affiliatedAuthor | Han Kyoung Choe | - |
| dc.contributor.alternativeName | 서희원 | - |
| dc.contributor.alternativeName | Sohee Kim | - |
| dc.contributor.alternativeName | 최한경 | - |
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