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Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior
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dc.contributor.advisor 최한경 -
dc.contributor.author Jiyoung Lee -
dc.date.accessioned 2022-08-17T16:00:14Z -
dc.date.available 2022-08-17T16:00:14Z -
dc.date.issued 2022 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000630783 en_US
dc.identifier.uri http://hdl.handle.net/20.500.11750/16802 -
dc.description Lateral habenula, Astrocyte, PLCη1, Depression -
dc.description.abstract -
dc.description.statementofresponsibility N -
dc.description.tableofcontents I. Introduction 1
II. Materials and Methods 7
III. Results 20
3.1 Deletion of PLCη1 in lateral habenula astrocyte with adeno-associated viral vector 20
3.2 PLCη1 in lateral habenula effect on depressive-like behavior 23
3.3 PLCη1 in lateral habenula did not effect the motor function and anxiety-like behavior 26
3.4 PLCη1 in lateral habenula did not alter working and fear memory 30
3.5 Deletion of astrocytic PLCη1disrupts tonic glutamate current in the LHb while sparing tonic GABA current 33
3.6 Impairment of extra synaptic long-term depression (LTD) in the deletion mice of astrocytic PLCη1 36
3.7 Astrocytic PLCη1 in lateral habenula disrupt synaptic function and regulate mood state 40
IV. Discussion 42
V. References 45
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dc.format.extent 50 -
dc.language eng -
dc.publisher DGIST -
dc.subject Lateral habenula, Astrocyte, PLCη1, Depression -
dc.title Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior -
dc.type Thesis -
dc.identifier.doi 10.22677/thesis.200000630783 -
dc.description.degree Master -
dc.contributor.department Department of Brain Sciences -
dc.identifier.bibliographicCitation Jiyoung Lee. (2022). Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior. doi: 10.22677/thesis.200000630783 -
dc.contributor.coadvisor Jeongyeon Kim -
dc.date.awarded 2022/08 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 이786 202208 -
dc.date.accepted 8/11/22 -
dc.contributor.alternativeDepartment 뇌과학과 -
dc.embargo.liftdate 2024-02-28 -
dc.contributor.affiliatedAuthor Jiyoung Lee -
dc.contributor.affiliatedAuthor Han Kyoung Choe -
dc.contributor.affiliatedAuthor Jeongyeon Kim -
dc.contributor.alternativeName 이지영 -
dc.contributor.alternativeName Han Kyoung Choe -
dc.contributor.alternativeName 김정연 -
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