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Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in Alzheimer’s Disease

Title
Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in Alzheimer’s Disease
Author(s)
Jung, Da HaeSon, GowoonKwon, Oh-HoonChang, Keun-AMoon, Cheil
Issued Date
2022-08
Citation
Pharmaceutics, v.14, no.8
Type
Article
Author Keywords
non-invasiveperipheralAlzheimer's diseasenasal discharge fluidbody fluidbiomarkerdiagnosis
Keywords
MILD COGNITIVE IMPAIRMENTBLOOD-BRAIN-BARRIERCEREBROSPINAL-FLUIDAMYLOID-BETASALIVARY ACETYLCHOLINESTERASEASSOCIATION WORKGROUPSDIAGNOSTIC GUIDELINESOLFACTORY DYSFUNCTIONNATIONAL INSTITUTEPROTEOME ANALYSIS
ISSN
1999-4923
Abstract
The key to current Alzheimer's disease (AD) therapy is the early diagnosis for prompt intervention, since available treatments only slow the disease progression. Therefore, this lack of promising therapies has called for diagnostic screening tests to identify those likely to develop full-blown AD. Recent AD diagnosis guidelines incorporated core biomarker analyses into criteria, including amyloid-beta (A beta), total-tau (T-tau), and phosphorylated tau (P-tau). Though effective, the accessibility of screening tests involving conventional cerebrospinal fluid (CSF)- and blood-based analyses is often hindered by the invasiveness and high cost. In an attempt to overcome these shortcomings, biomarker profiling research using non-invasive body fluid has shown the potential to capture the pathological changes in the patients' bodies. These novel non-invasive body fluid biomarkers for AD have emerged as diagnostic and pathological targets. Here, we review the potential peripheral biomarkers, including non-invasive peripheral body fluids of nasal discharge, tear, saliva, and urine for AD.
URI
http://hdl.handle.net/20.500.11750/16873
DOI
10.3390/pharmaceutics14081532
Publisher
MDPI AG
Related Researcher
  • 문제일 Moon, Cheil 뇌과학과
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
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Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles

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