Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, J.A. | - |
dc.contributor.author | Shin, J.M. | - |
dc.contributor.author | Song, S.H. | - |
dc.contributor.author | Kim, C.H. | - |
dc.contributor.author | Son, S. | - |
dc.contributor.author | Shin, S. | - |
dc.contributor.author | Park, J.H. | - |
dc.date.accessioned | 2022-11-16T17:10:13Z | - |
dc.date.available | 2022-11-16T17:10:13Z | - |
dc.date.created | 2022-02-28 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/17145 | - |
dc.description.abstract | Therapeutic cancer vaccines have attracted attention because of their potential to prime cytotoxic T cells, which are highly antigen (Ag)-specific, allowing personalized cancer immunotherapy. However, because of their low immunogenicity, cancer vaccines have been used in only a few types of cancers in clinics, primarily because of the poor Ag presentation of dendritic cells (DCs). To address these limitations of cancer vaccines, we show that ‘find-me’ signaling polymeric microparticles (F-PMs) bearing tumor lysate as an Ag can efficiently recruit DCs and facilitate antigen presentation. When subcutaneously injected into tumor-bearing mice, F-PMs significantly increased mature DCs in tumor-draining lymph nodes by eliciting adenosine triphosphate (ATP)-induced chemotaxis, resulting in high antitumor efficacy. CD8+ cytotoxic T cells were remarkably enriched in the tumor microenvironment following co-administration of an immune checkpoint inhibitor with F-PMs. We demonstrated that F-PMs elicit a robust antitumor immune response, which may provide a promising therapeutic option for cancer treatment. © 2022 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Recruitment of dendritic cells using ‘find-me’ signaling microparticles for personalized cancer immunotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121412 | - |
dc.identifier.wosid | 000780193300001 | - |
dc.identifier.scopusid | 2-s2.0-85124702829 | - |
dc.identifier.bibliographicCitation | Biomaterials, v.282 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Cancer antigen | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | Find-me signal | - |
dc.subject.keywordAuthor | Immune checkpoint inhibitors | - |
dc.subject.keywordAuthor | Personalized therapy | - |
dc.subject.keywordAuthor | Polymeric microparticle | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DEATH | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 282 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering; Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical; Materials Science, Biomaterials | - |
dc.type.docType | Article | - |
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