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Ginsenoside Rg3-enriched Korean red ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium

Title
Ginsenoside Rg3-enriched Korean red ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium
Author(s)
Lee, Seoung-WooBaek, Su-MinLee, Young-JinKim, Tae-UnYim, Jae-HyukSon, Jun-HyeokKim, Hee-YeonKang, Kyung-KuKim, Jong HunRhee, Man HeePark, Sang-JoonChoi, Seong-KyoonPark, Jin-Kyu
Issued Date
2023-05
Citation
Journal of Ginseng Research, v.47, no.3, pp.429 - 439
Type
Article
Author Keywords
chemotaxisginsenosideliver sinusoidal endotheliumNAFLDVCAM-1
Keywords
INJURYPATHOGENESISROLESMODELCELLS
ISSN
1226-8453
Abstract
Background: The incidence and clinical importance of nonalcoholic fatty liver disease (NAFLD) has emerged. However, effective therapeutic strategies for NAFLD have yet to be found. Panax ginseng (P. ginseng) is a traditional herb in Eastern Asia with therapeutic effects in many chronic disorders. However, the precise effects of ginseng extract on NAFLD are currently unknown. In present study, the therapeutic effects of Rg3-enriched red ginseng extract (Rg3-RGE) on the progression of NAFLD were explored. Methods: Twelve-week-old C57BL/6 male mice were fed a chow or western diet supplemented with high sugar water solution with or without Rg3-RGE. Histopathology, immunohistochemistry, immunofluorescence, serum biochemistry, western blot analysis, and quantitative RT-PCR were used for in vivo experiment. Conditionally immortalized human glomerular endothelial cell (CiGEnC) and primary liver sinusoidal endothelial cells (LSECs) were used for in vitro experiments. Results: Eight weeks of Rg3-RGE treatment significantly attenuated the inflammatory lesions of NAFLD. Furthermore, Rg3-RGE inhibited the inflammatory infiltrate in liver parenchyma and the expression of adhesive molecules to LSECs. Moreover, the Rg3-RGE exhibited similar patterns on the in vitro assays. Conclusion: The results demonstrate that Rg3-RGE treatment ameliorates NAFLD progression by inhibiting chemotaxis activities in LSECs. © 2022
URI
http://hdl.handle.net/20.500.11750/17224
DOI
10.1016/j.jgr.2022.10.005
Publisher
고려인삼학회
Related Researcher
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Appears in Collections:
Division of Biomedical Technology 1. Journal Articles

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