Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Seoung-Woo | - |
dc.contributor.author | Lee, Young-Jin | - |
dc.contributor.author | Baek, Su-Min | - |
dc.contributor.author | Kang, Kyung-Ku | - |
dc.contributor.author | Kim, Tae-Un | - |
dc.contributor.author | Yim, Jae-Hyuk | - |
dc.contributor.author | Kim, Hee-Yeon | - |
dc.contributor.author | Han, Se-Hyeon | - |
dc.contributor.author | Choi, Seong-Kyoon | - |
dc.contributor.author | Park, Sang-Joon | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Park, Jin-Kyu | - |
dc.date.accessioned | 2022-12-02T11:10:11Z | - |
dc.date.available | 2022-12-02T11:10:11Z | - |
dc.date.created | 2022-06-28 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/17226 | - |
dc.description.abstract | In previous studies, the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD) has been recognized. However, the specific therapeutic strategies or drugs have not been discovered. Vitamin C is a water-soluble antioxidant and is a cofactor in many important biosynthesis pathways. Recently, many researchers have reported that the mega-dose vitamin C treatment had positive effects on various diseases. However, the precise relationship between mega-dose vitamin C and NAFLD has not been completely elucidated. This study has been designed to discover the effects of mega-dose vitamin C on the progression of NAFLD. Twelve-week-old wild-type C57BL6 mice were fed chow diets and high-fat and high-fructose diet (fast-food diet) ad libitum for 11 weeks with or without of vitamin C treatment. Vitamin C was administered in the drinking water (1.5 g/L). In this study, 11 weeks of the mega-dose vitamin C treatment significantly suppressed the development of nonalcoholic steatohepatitis (NASH) independently of the catabolic process. Vitamin C supplements in fast-food diet fed mice significantly decreased diet ingestion and increased water intake. Histopathological analysis revealed that the mice fed a fast-food diet with vitamin C water had a mild renal injury suggesting osmotic nephrosis due to fructose-mediated purine derivatives. These data suggest that the mega-dose vitamin C treatment suppresses high-fructose-diet-mediated NAFLD progression by decreasing diet ingestion and increasing water intake. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Mega-Dose Vitamin C Ameliorates Nonalcoholic Fatty Liver Disease in a Mouse Fast-Food Diet Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/nu14112195 | - |
dc.identifier.scopusid | 2-s2.0-85130996468 | - |
dc.identifier.bibliographicCitation | Nutrients, v.14, no.11 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | vitamin C | - |
dc.subject.keywordAuthor | nonalcoholic fatty liver disease (NAFLD) | - |
dc.subject.keywordAuthor | uric acid | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordAuthor | fructose | - |
dc.subject.keywordPlus | URICASES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INJURY | - |
dc.citation.number | 11 | - |
dc.citation.title | Nutrients | - |
dc.citation.volume | 14 | - |