Cited 7 time in
Cited 7 time in
Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways
- Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways
- Sims, Jennie R.; Ow, Maria C.; Nishiguchi, Mailyn A.; Kim, Kyuhyung; Sengupta, Piali; Hall, Sarah E.
- DGIST Authors
- Kim, Kyuhyung
- Issue Date
- eLife, 5
- Article Type
- Animal Cell; Caenorhabditis Elegans; Chromatin Assembly and Disassembly; Controlled Study; Down-Regulation; Fluorescence in Situ Hybridization; Gene Expression; Immunoprecipitation; Mutagenesis; Non-Human; Polymerase Chain Reaction; Protein Expression; RNA Interference; Smelling; Transforming Growth Factor Beta; Zinc Finger Protein
- Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once conditions improve (postdauers). Here we show that the osm-9 TRPV channel gene is a target of developmental programming and is down-regulated specifically in the ADL chemosensory neurons of postdauer adults, resulting in a corresponding altered olfactory behavior that is mediated by ADL in an OSM-9-dependent manner. We identify a cis-acting motif bound by the DAF-3 SMAD and ZFP-1 (AF10) proteins that is necessary for the differential regulation of osm-9, and demonstrate that both chromatin remodeling and endo-siRNA pathways are major contributors to the transcriptional silencing of the osm-9 locus. This work describes an elegant mechanism by which developmental experience influences adult phenotypes by establishing and maintaining transcriptional changes via RNAi and chromatin remodeling pathways.
- eLife Sciences Publications Ltd.
- Related Researcher
Kim, Kyu Hyung
The K. Kim Lab of Neurobehavior and Neural Circuits
Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
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- Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles
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