Cited 1 time in
Cited 2 time in
Transcriptional regulatory network during development in the olfactory epithelium
- Transcriptional regulatory network during development in the olfactory epithelium
- Im, Seung Yeong; Moon, Cheil
- DGIST Authors
- Moon, Cheil
- Issue Date
- BMB Reports, 48(11), 599-608
- Article Type
- Neurogenesis; Olfactory epithelium; Regeneration; Stem cell; Transcription factor
- Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.
- Korean Society for Molecular and Cellular Biology
- Related Researcher
Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
There are no files associated with this item.
- Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.