Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Artan, Murat | - |
dc.contributor.author | Jeong, Dae-Eun | - |
dc.contributor.author | Lee, Dongyeop | - |
dc.contributor.author | Kim, Young-Il | - |
dc.contributor.author | Son, Heehwa G. | - |
dc.contributor.author | Husain, Zahabiya | - |
dc.contributor.author | Kim, Jin Mahn | - |
dc.contributor.author | Altintas, Ozlem | - |
dc.contributor.author | Kim, Kyu Hyung | - |
dc.contributor.author | Alcedo, Joy | - |
dc.contributor.author | Lee, Seung-Jae V. | - |
dc.date.available | 2017-07-11T05:32:18Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2688 | - |
dc.description.abstract | Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans’ life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs. © 2016 Artan et al. | - |
dc.language | English | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.title | Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides | - |
dc.type | Article | - |
dc.identifier.doi | 10.1101/gad.279448.116 | - |
dc.identifier.scopusid | 2-s2.0-84965082408 | - |
dc.identifier.bibliographicCitation | Genes and Development, v.30, no.9, pp.1047 - 1057 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | Aging | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | C. Elegans | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | Caenorhabditis Elegans | - |
dc.subject.keywordPlus | Cation Channel | - |
dc.subject.keywordPlus | DAF-16 | - |
dc.subject.keywordPlus | DAF-16/FOXO | - |
dc.subject.keywordPlus | DAF 28 Protein | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | DROSOPHILA LIFE-SPAN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | Food Deprivation | - |
dc.subject.keywordPlus | HEAT-SHOCK FACTOR | - |
dc.subject.keywordPlus | INS 6 Protein | - |
dc.subject.keywordPlus | Insulin-Like Peptide | - |
dc.subject.keywordPlus | Lifespan | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | MemBER | - |
dc.subject.keywordPlus | Neuroendocrine Specific Protein | - |
dc.subject.keywordPlus | Neurons | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | NUCLEOTIDE-GATED CHANNEL | - |
dc.subject.keywordPlus | Optogenetics | - |
dc.subject.keywordPlus | Priority Journal | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Sensory Nerve Cell | - |
dc.subject.keywordPlus | Sensory Neurons | - |
dc.subject.keywordPlus | Tax 2 Protein | - |
dc.subject.keywordPlus | Tax 4 Protein | - |
dc.subject.keywordPlus | Transcription Factor DAF 16 | - |
dc.subject.keywordPlus | Transcription Factor FOXO | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.citation.endPage | 1057 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1047 | - |
dc.citation.title | Genes and Development | - |
dc.citation.volume | 30 | - |
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