Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kwon, Ok-Seon | - |
dc.contributor.author | Oh, Ensel | - |
dc.contributor.author | Park, Jeong-Rak | - |
dc.contributor.author | Lee, Ji-Seon | - |
dc.contributor.author | Bae, Gab-Yong | - |
dc.contributor.author | Koo, Jae-Hyung | - |
dc.contributor.author | Kim, Hyongbum | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Choi, Young Soo | - |
dc.contributor.author | Kim, Jhingook | - |
dc.contributor.author | Cha, Hyuk-Jin | - |
dc.date.available | 2017-07-11T05:42:32Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-12-08 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2799 | - |
dc.description.abstract | While metastasis, the main cause of lung cancer-related death, has been extensively studied, the underlying molecular mechanism remains unclear. A previous clinicogenomic study revealed that expression of N-acetylgalactosaminyltransferase (GalNAc-T14), is highly inversely correlated with recurrence-free survival in those with non-small cell lung cancer (NSCLC). However, the underlying molecular mechanism(s) has not been determined. Here, we showed that GalNAc-T14 expression was positively associated with the invasive phenotype. Microarray and biochemical analyses revealed that HOXB9, the expression of which was increased in a GalNAc- T14-dependent manner, played an important role in metastasis. GalNAc-T14 increased the sensitivity of the WNT response and increased the stability of the ß-catenin protein, leading to induced expression of HOXB9 and acquisition of an invasive phenotype. Pharmacological inhibition of ß-catenin in GalNAc-T14-expressing cancer cells suppressed HOXB9 expression and invasion. A meta-analysis of clinical genomics data revealed that expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival and increased hazard risk, suggesting that targeting ß-catenin within the GalNAc-T14/WNT/HOXB9 axis may be a novel therapeutic approach to inhibit metastasis in NSCLC. | - |
dc.publisher | Impact Journals LLC | - |
dc.title | GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.6019 | - |
dc.identifier.scopusid | 2-s2.0-84951735816 | - |
dc.identifier.bibliographicCitation | Oncotarget, v.6, no.39, pp.41916 - 41928 | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | GalNAc-T14 | - |
dc.subject.keywordAuthor | WNT/TCF pathway | - |
dc.subject.keywordAuthor | HOXB9 | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Animal Model | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Beta Catenin | - |
dc.subject.keywordPlus | Cancer Prognosis | - |
dc.subject.keywordPlus | Cancer Survival | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | Down Regulation | - |
dc.subject.keywordPlus | Enzyme Activity | - |
dc.subject.keywordPlus | GalNAc-T14 | - |
dc.subject.keywordPlus | Genomics | - |
dc.subject.keywordPlus | HOXB9 | - |
dc.subject.keywordPlus | HOXB9 Protein | - |
dc.subject.keywordPlus | Invasion | - |
dc.subject.keywordPlus | Lung Adenocarcinoma | - |
dc.subject.keywordPlus | Lung Metastasis | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Metastasis | - |
dc.subject.keywordPlus | Microarray Analysis | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | N Acetylgalactosaminyltransferase | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Oncoprotein | - |
dc.subject.keywordPlus | Phenotype | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Protein Stability | - |
dc.subject.keywordPlus | Protein Targeting | - |
dc.subject.keywordPlus | Recurrence Free Survival | - |
dc.subject.keywordPlus | Sensitivity Analysis | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.subject.keywordPlus | Up-Regulation | - |
dc.subject.keywordPlus | Wnt Protein | - |
dc.subject.keywordPlus | Wnt/TCF Pathway | - |
dc.citation.endPage | 41928 | - |
dc.citation.number | 39 | - |
dc.citation.startPage | 41916 | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 6 | - |
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