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Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis

Title
Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis
Author(s)
Lee, Hyo-JeongSanetuntikul, JakkidChoi, Eun-SookLee, Bo RamKim, Jung-HeeKim, EunjooShanmugam, Sangaraju
Issued Date
2015-12
Citation
International Journal of Nanomedicine, v.10, no.1, pp.271 - 282
Type
Article
Author Keywords
graphitic carbon–encapsulated magnetic nanoparticlesiron oxideone-pot synthesisphotothermal cancer therapy
Keywords
GRAPHENE OXIDENANOPARTICLESNANOTUBESNANOCRYSTALSCELLSNANOCOMPOSITESDELIVERYPLASMA
ISSN
1176-9114
Abstract
We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriamine-pentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm2). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. © 2015 Lee et al.
URI
http://hdl.handle.net/20.500.11750/2968
DOI
10.2147/IJN.S73128
Publisher
Dove Medical Press Ltd
Related Researcher
  • 김은주 Kim, Eunjoo 전자정보시스템연구부
  • Research Interests Biomarker; liquid biopsy; molecular diagnosis; nanobiosensor; drug delivery; exosome
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Appears in Collections:
Department of Energy Science and Engineering Advanced Energy Materials Laboratory 1. Journal Articles
Companion Diagnostics and Medical Technology Research Group 1. Journal Articles
Division of Electronics & Information System 1. Journal Articles

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