Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyo-Jeong | - |
dc.contributor.author | Sanetuntikul, Jakkid | - |
dc.contributor.author | Choi, Eun-Sook | - |
dc.contributor.author | Lee, Bo Ram | - |
dc.contributor.author | Kim, Jung-Hee | - |
dc.contributor.author | Kim, Eunjoo | - |
dc.contributor.author | Shanmugam, Sangaraju | - |
dc.date.available | 2017-07-11T06:11:59Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2968 | - |
dc.description.abstract | We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriamine-pentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm2). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. © 2015 Lee et al. | - |
dc.language | English | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S73128 | - |
dc.identifier.scopusid | 2-s2.0-84920163824 | - |
dc.identifier.bibliographicCitation | International Journal of Nanomedicine, v.10, no.1, pp.271 - 282 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | graphitic carbon–encapsulated magnetic nanoparticles | - |
dc.subject.keywordAuthor | iron oxide | - |
dc.subject.keywordAuthor | one-pot synthesis | - |
dc.subject.keywordAuthor | photothermal cancer therapy | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOTUBES | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | NANOCOMPOSITES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.citation.endPage | 282 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 271 | - |
dc.citation.title | International Journal of Nanomedicine | - |
dc.citation.volume | 10 | - |