Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Chul | - |
dc.contributor.author | Kim, Eunjoo | - |
dc.contributor.author | Jeong, Sang Won | - |
dc.contributor.author | Ha, Tae-Lin | - |
dc.contributor.author | Park, Sang-Im | - |
dc.contributor.author | Lee, Se Guen | - |
dc.contributor.author | Lee, Sung Jun | - |
dc.contributor.author | Lee, Seung Woo | - |
dc.date.available | 2017-07-11T06:12:53Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2977 | - |
dc.description.abstract | Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia. © The Royal Society of Chemistry. | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c5nr04130a | - |
dc.identifier.scopusid | 2-s2.0-84942855709 | - |
dc.identifier.bibliographicCitation | Nanoscale, v.7, no.39, pp.16470 - 16480 | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | CONTROLLED DRUG-RELEASE | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | NANOCAPSULES | - |
dc.subject.keywordPlus | CIRCULATION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | VEHICLES | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.citation.endPage | 16480 | - |
dc.citation.number | 39 | - |
dc.citation.startPage | 16470 | - |
dc.citation.title | Nanoscale | - |
dc.citation.volume | 7 | - |
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