Department of Energy Science and Engineering
Electrochemistry Laboratory for Sustainable Energy(ELSE)
1. Journal Articles
Propylene Cross-Bridged Macrocyclic Bifunctional Chelator: A New Design for Facile Bioconjugation and Robust Cu-64 Complex Stability
- Title
- Propylene Cross-Bridged Macrocyclic Bifunctional Chelator: A New Design for Facile Bioconjugation and Robust Cu-64 Complex Stability
- Author(s)
- Pandya, DN[Pandya, Darpan N.] ; Bhatt, N[Bhatt, Nikunj] ; An, GI[An, Gwang Il] ; Ha, YS[Ha, Yeong Su] ; Soni, N[Soni, Nisarg] ; Lee, H[Lee, Hochun] ; Lee, YJ[Lee, Yong Jin] ; Kim, JY[Kim, Jung Young] ; Lee, W[Lee, Woonghee] ; Ahn, H[Ahn, Heesu] ; Yoo, J[Yoo, Jeongsoo]
- DGIST Authors
- Lee, H[Lee, Hochun]
- Issued Date
- 2014-09-11
- Type
- Article
- Article Type
- Article
- Subject
- 4,11 Bis(Carboxymethyl) 1,4,8,11 Tetraazabicyclo[6,6,3]Hexadecane Isothiocyanate Cyclic Arginylglycylaspartic Acid ; Alkene ; Alkenes ; Alkylation ; Animal ; Animal Experiment ; Animal Model ; Animals ; Arginyl-Glycyl-Aspartic Acid ; Binding Affinity ; Carboxylic Acid ; Chelating Agent ; Chelating Agents ; Chemical Model ; Chemical Structure ; Chemistry ; Complex Formation ; Controlled Study ; Coordination Complexes ; Coordination Compound ; Copper ; Copper 64 ; Copper Radioisotopes ; Cyclam ; Deprotection Reaction ; Drug Conjugation ; Drug Design ; Drug Distribution ; Drug Stability ; Drug Synthesis ; Electrochemistry ; Female ; Glioblastoma ; Heterocyclic Compound ; Heterocyclic Compounds ; High Performance Liquid Chromatography ; Human ; Humans ; Isotope Labeling ; Macrocyclic Compound ; Macrocyclic Compounds ; Metabolism ; Mice ; Mice, Nude ; Models, Chemical ; Molecular Structure ; Mouse ; Non-Human ; Nude Mouse ; Oligopeptide ; Oligopeptides ; Partition Coefficient ; Pathology ; Positron-Emission Tomography ; Positron-Emission Tomography (PET) ; Procedures ; Propylene ; Rat ; Rats ; Synthesis ; Tissue Distribution ; Transplantation, Heterologous ; Unclassified Drug ; Xenograft
- ISSN
- 0022-2623
- Abstract
- The first macrocyclic bifunctional chelator incorporating propylene cross-bridge was efficiently synthesized from cyclam in seven steps. After the introduction of an extra functional group for facile conjugation onto the propylene cross-bridge, the two carboxylic acid pendants could contribute to strong coordination of Cu(II) ions, leading to a robust Cu complex. The cyclic RGD peptide conjugate of PCB-TE2A-NCS was prepared and successfully radiolabeled with 64Cu ion. The radiolabeled peptide conjugate was evaluated in vivo through a biodistribution study and animal PET imaging to demonstrate high tumor uptake with low background. © 2014 American Chemical Society.
- Publisher
- American Chemical Society
- Related Researcher
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Lee, Hochun 에너지공학과
- Research Interests Lithium-ion batteries; Novel Materials for rechargeable batteries; Novel energy conversion;storage systems; Electrochemistry; 리튬이차전지; 이차전지용 신규 전극 및 전해액; 신규 에너지변환 및 저장 시스템; 전기화학
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