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dc.contributor.authorLee, Yongjinko
dc.contributor.authorKim, Eun-Kyoungko
dc.date.available2017-07-11T06:34:58Z-
dc.date.created2017-04-10-
dc.date.created2017-04-10-
dc.date.issued2013-07-
dc.identifier.citationExperimental and Molecular Medicine, v.45-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://hdl.handle.net/20.500.11750/3225-
dc.description.abstractCircadian clocks regulate behavioral, physiological and biochemical processes in a day/night cycle. Circadian oscillators have an essential role in the coordination of physiological processes with the cyclic changes in the physical environment. Such mammalian circadian clocks composed of the positive components (BMAL1 and CLOCK) and the negative components (CRY and PERIOD (PER)) are regulated by a negative transcriptional feedback loop in which PER is rate-limiting for feedback inhibition. In addition, posttranslational modification of these components is critical for setting or resetting the circadian oscillation. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. AMP-activated protein kinase (AMPK) in the brain and peripheral tissue is a crucial cellular energy sensor that has a role in metabolic control. AMPK-mediated phosphorylation of CRY and Casein kinases I regulates the negative feedback control of circadian clock by proteolytic degradation. AMPK can also modulate the circadian rhythms through nicotinamide adenine dinucleotide- dependent regulation of silent information regulator 1. Growing evidence elucidates the AMPK-mediated controls of circadian clock in metabolic diseases such as obesity and diabetes. In this review, we summarize the current comprehension of AMPK-mediated regulation of the circadian rhythms. This will provide insight into understanding how their components regulate the metabolism. © 2013 KSBMB.-
dc.publisherNature Publishing Group-
dc.subject5 Amino 4 Imidazolecarboxamide Riboside-
dc.subjectAMP-Activated Protein Kinases-
dc.subjectAMPK-
dc.subjectAnimal-
dc.subjectAnimals-
dc.subjectBMAL1 Gene-
dc.subjectCasein Kinase I-
dc.subjectCircadian Clock-
dc.subjectCircadian Clocks-
dc.subjectCircadian Rhythm-
dc.subjectCKI-
dc.subjectClock Gene-
dc.subjectCRY-
dc.subjectCry1 Gene-
dc.subjectCry2 Gene-
dc.subjectCryptochrome-
dc.subjectCryptochrome 1-
dc.subjectCryptochrome 2-
dc.subjectCryptochromes-
dc.subjectEnergy Balance-
dc.subjectEnzyme Activation-
dc.subjectEnzyme Phosphorylation-
dc.subjectFeedback System-
dc.subjectGene-
dc.subjectGene Expression Regulation-
dc.subjectHuman-
dc.subjectHumans-
dc.subjectHydroxymethylglutaryl Coenzyme A Reductase Kinase-
dc.subjectIntracellular Signaling-
dc.subjectMetabolic Disorder-
dc.subjectMetabolic Regulation-
dc.subjectMetabolism-
dc.subjectMetformin-
dc.subjectMolecular Clock-
dc.subjectMolecular Interaction-
dc.subjectMolecular Sensor-
dc.subjectNeuromodulation-
dc.subjectNicotinamide Adenine Dinucleotide-
dc.subjectNon-Human-
dc.subjectNon-Insulin Dependent Diabetes Mellitus-
dc.subjectPalmitic Acid-
dc.subjectPER1 Gene-
dc.subjectPER1 Protein-
dc.subjectPER2 Gene-
dc.subjectPER2 Protein-
dc.subjectProtein BMAL1-
dc.subjectProtein Degradation-
dc.subjectProtein Function-
dc.subjectProtein Processing-
dc.subjectReview-
dc.subjectSIRT1-
dc.subjectSirtuin-
dc.subjectSirtuin1-
dc.subjectSirtuins-
dc.subjectTranscription Factor Clock-
dc.titleAMP-activated protein kinase as a key molecular link between metabolism and clockwork-
dc.typeArticle-
dc.identifier.doi10.1038/emm.2013.65-
dc.identifier.wosid000328122400004-
dc.identifier.scopusid2-s2.0-84882966981-
dc.type.localArticle(Overseas)-
dc.type.rimsART-
dc.description.journalClass1-
dc.contributor.localauthorKim, Eun-Kyoung-
dc.identifier.citationVolume45-
dc.identifier.citationTitleExperimental and Molecular Medicine-
dc.type.journalArticleReview-


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